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甘草酸苷治疗非酒精性脂肪性肝炎的系统评价与Meta分析 被引量:9

Systematic Evaluation and Meta Analysis on Nonalcoholic Steatohepatitis Treated with Glycyrrhizin
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摘要 目的评价甘草酸苷治疗非酒精性脂肪性肝炎(NASH)的有效性与安全性。方法计算机检索9个中英文数据库(时间均自建库至2013年12月),纳入甘草酸苷治疗NASH随机对照试验(RCT)文献,对其方法学质量及终点指标行定性与定量合成分析。结果共纳入5个RCT合计362例NASH受试者,其方法学质量均属于高偏倚风险。所有RCT的试验组采用甘草酸苷或结合中西药治疗,对照组采用西药治疗,均未报告主要终点,而仅报告次要终点指标。对报告的次要终点指标行Meta分析结果显示,试验组治疗后转氨酶复常率、症状好转率、肝脏影像学改善效果优于对照组(P<0.05)。结论甘草酸苷治疗NASH安全有效,但由于所纳入RCT方法学质量均较低,需要开展更为严格的RCT以提供充分证据支持临床应用甘草酸苷治疗NASH。 Objective To evaluate the effectiveness and safety of glycyrrhizin in treatment of nonalcoholic steatohepatitis( NASH). Methods Nine database of Chinese and English versions were retrieved( till December 2013 since the database setup). The RCT literatures on the treatment of NASH with glycyrrhizin were collected. The qualitative and quantitative synthetic analysis was performed on the methodological quality and endpoint indices. Results Totally,362 cases of NASH from 5 RCTs were collected and their methodological quality was high- bias risk. All of RCT groups adopted glycyrrhizin or integrated Chinese and western medicine treatment. In the control group,the western medicine was applied. The main endpoints were not reported. The secondary endpoints were only reported. Meta analysis on the secondary endpoints showed: in RCT groups,the results of transaminase recovery rate,symptom recovery rate and liver imaging improvement were all better than those in the control group( P < 0. 05). Conclusion Glycyrrhizin is safe and effective in treatment of NASH. But because of the low methodological quality of the involved RCTs,it is required to develop more strict RCTs so that the adequate evidences can be provided to support the clinical application of glycyrrhizin in the treatment of NASH.
出处 《世界中西医结合杂志》 2015年第2期265-271,共7页 World Journal of Integrated Traditional and Western Medicine
基金 中国中医科学院中央级公益性科研院所科研基本业务费自主选题项目(ZZ070816)
关键词 甘草酸苷 非酒精性脂肪性肝炎 中药有效组分 系统评价与Meta分析 Glycyrrhizin Nonalcoholic Steatohepatitis Effective Components of Chinese Medicine Systematic Evaluation and Meta Analysis
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