摘要
目的探讨疏肝健脾中药联合化疗治疗晚期乳腺癌患者的临床疗效。方法将73例IV期乳腺癌住院患者,随机分为两组,其中治疗组37例,对照组36例,两组均给予GC方案化疗,治疗组加服逍遥散加减方治疗。连续观察2个化疗周期,观察两周期后两组的近期疗效、中医证候改善情况、毒副作用、KPS评分情况、肿瘤标志物。结果治疗组治疗后有效率和稳定率分别为37.8%和78.4%,对照组分别为36.1%和72.2%;两组患者中医证候总评分比较差异无统计学意义,但治疗组在改善腹胀、胁肋胀痛方面有效率优于对照组(P<0.01,P<0.05)。治疗组Ⅳ度消化道反应发生率明显低于对照组(P<0.05)。治疗组肿瘤标志物CEA、CA153改善情况较对照组明显(P<0.01,P<0.05)。治疗组治疗后KPS评分高于对照组(P<0.05)。结论疏肝健脾法可提高乳腺癌患者的生活质量,减轻化疗药物的消化道副作用。
Objective To explore the clinical efficacy on advanced breast cancer treated with the herbal medicine for smoothing liver qi and strengthening spleen combined with chemotherapy( combined therapy). Methods Seventy- three inpatients of breast cancer of IV stage were randomly divided into a treatment group( n = 37,) and a control group( n = 36). GC chemotherapy was applied in the two groups. In the treatment group,the modified xiaoyao san was added. The observation was done continuously for 2 cycles of chemotherapy. The short- term effect,TCM syndromes,toxic side effects,KPS score and tumor markers were observed. Results The effective rate was 37. 8% and the stable rate was 78. 4% in the treatment group and was 36. 1% and 72. 2% in the control group respectively. There was no statistical difference in the total scores of TCM syndrome between the two groups. But the effective rates for the improvements in abdominal distending pain and distending pain in the hypochondriac region were higher than those of the control group( P < 0. 01,P < 0. 05). The incidence rate of IV degree gastrointestinal reaction was lower than that of the control group( P < 0. 05). The improvements in CEA and CA153 were apparent as compared with the control group( P < 0. 01,P < 0. 05). KPS score in the treatment group was higher than that of the control group after treatment( P < 0. 05). Conclusions The therapy for smoothing liver qi and strengthening spleen improves the quality of life for advanced breast cancer patients,and alleviate gastrointestinal side effects induced by chemotherapy.
出处
《世界中西医结合杂志》
2016年第6期815-818,共4页
World Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金(81503517)
关键词
乳腺癌
化疗
疏肝健脾
生活质量
Breast Cancer
Chemotherapy
Smoothing Liver Qi and Strengthening Spleen
Quality of Life
