摘要
目的老年性阴道炎多发于绝经后老年妇女,其治疗原则是抑制病原菌生长及增强阴道抵抗力。本研究评价硝呋太尔制霉素阴道软胶囊治疗老年性阴道炎的疗效,为临床用药提供指导。方法选取2016-01-10-2018-01-10开封新区妇幼保健院收治的120例老年性阴道炎患者作为研究对象,其中观察组(60例)采用硝呋太尔制霉素阴道软胶囊治疗,对照组(60例)采用甲硝唑栓治疗,两组患者均每晚用药1粒,治疗14d停药。对比两组患者的疗效、阴道pH值变化、不良反应发生率和复发率。结果观察组治疗总有效率为90.00%,高于对照组的66.67%,χ~2=9.624,P=0.002。治疗前,观察组患者阴道pH值为5.93±0.63,对照组的为5.89±0.78,差异无统计学意义,t=0.687,P=0.504;治疗后,观察组患者阴道pH值为5.03±0.52,对照组的为5.67±0.83,观察组患者阴道pH值低于对照组,t=-2.360,P=0.033。观察组和对照组不良反应发生率分别为5.00%和10.00%,差异无统计学意义,χ~2=1.081,P=0.298。观察组复发率为13.16%,显著低于对照组的40.00%,χ~2=5.989,P=0.032。结论硝呋太尔制霉素阴道软胶囊治疗老年性阴道炎疗效好,复发率低。
OBJECTIVE Senile vaginitis(SV)mostly occurs in postmenopausal elderly women.Its treatment principle is to inhibit the growth of pathogenic bacteria and enhance vaginal resistance.This paper evaluates the efficacy of nifuratel nysfungin vaginal soft capsules in treatment in the treatment of senile vaginitis and provides guidance for clinical medication.METHODS A total of 120 SV patients admitted to our hospital from January 10,2016 to January 10,2018 were selected as the research objects.They were randomly divided into observation group and control group with 60 cases in each group.Patients in the observation group were treated with nifuratel nysfungin vaginal soft capsules and those in the control group were treated with metronidazole suppository.Both of the groups were treated once a night.After 14 days of treatment,the clinical efficacy,vaginal pH and incidence of adverse reactions of the two groups were compared.The recurrence rate was observed after six months of follow-up.RESULTS The total effective rate of the observation group was90.00%,which was significantly higher than 66.67%of the control group(χ~2=9.624,P=0.002).Before treatment,the vaginal pH value of the observation group was 5.93±0.63 and that of the control group was 5.89±0.78.There was no significant difference in the vaginal pH value between the two groups(t=0.687,P=0.504).After treatment,the vaginal pH value of the observation group was 5.03±0.52 and that of the control group was 5.67±0.83.The vaginal pH value of the observation group was significantly lower than that of the control group(t=-2.360,P=0.033).The incidence of adverse reactions in the observation group and the control group were 5.00%and 10.00%,respectively,with no significant difference(χ~2=1.081,P=0.298).The recurrence rate of the observation group was 13.16%,which was significantly lower than 40.00%of the control group(χ~2=5.989,P=0.032).CONCLUSION The nifuratel nysfungin vaginal soft capsule is effective in the treatment of senile vaginitis with low recurrence rate.
作者
陈娟
刘英杰
CHEN Juan;LIU Ying-jie(Department of Gynecology and Obstetrics,Kaifeng New District Maternal and Child Health Care Hospital,Kaifeng475002,P.R.China;Institute of Pathogenic Biology,School of Basic Medical Sciences,Henan University,Kaifeng475004,P.R.China)
出处
《社区医学杂志》
2019年第4期217-219,共3页
Journal Of Community Medicine
关键词
硝呋太尔制霉素阴道软胶囊
甲硝唑栓
老年性阴道炎
PH值
nifuratel nysfungin vaginal soft capsule
metronidazole suppository
senile vaginitis
pH value
