摘要
5日龄雏鹅口服感染小鹅瘟强毒,观察感染后6、12、24、48、72、96、120h及发病致死鹅的小肠(包括十二指肠、空肠和回肠)、心、肝、肾、胰、脾、腔上囊等器官组织的病变发展规律。其结果为肠道最先出现病变,在感染后6h,即见十二指肠少量绒毛顶端上皮发生脱落;随着感染时间的延长,坏死脱落向绒毛基部发展,绒毛和粘膜固有层炎性细胞浸润逐渐增多。病鹅死之后,整个小肠绒毛上皮及肠腺上皮均发生脱落和坏死,固有层内有大量炎性细胞浸润,局部发生凝固性坏死。心、肝、肾、胰、脾和腔上囊等实质器官在感染初期主要表现为郁血、水肿和间质炎性细胞浸润,后期则表现为实质变化,实质细胞发生萎缩、变性,甚至局灶性坏死。电镜观察表明:肠道病变依次从十二指肠发展至空肠和回肠;感染初期,病毒主要引起肠绒毛顶端上皮的坏死脱落,以后逐渐向绒毛基部发展,固有层裸露,最终绒毛变形,结构消失。
Five-day-old goslings were infected with virulent gosling plague virus by oral administration. The infected goslings were killed at 6, 12, 24, 48, 72, 96 and 120 hours postinfection and the dynamic lesions of small intestines (duodenum, jejunum and ileum), heart, liver, kidney, pancreas, spleen and cloacal bursa were studied exhaustively. The first sign of changes found in the small intestine was the epithelia falling off the villus tip at 6 hours postinfection. Then the epithelia necrosed to the villus base. Meanwhile, the number of inflammatory cells infiltrating in the lamina propria increased gradually. The postmortem changes of infected goslings showed that the villus epithelia and intestinal glands necrosed and fell off the lamina propria in the whole small intestines with a large number of inflammatory cells infiltrated in the lamina propria. At the early stage of infection the lesions found in heart, liver, kidney, pancreas and clocal were congestion and edema with inflammatory cells infiltrated in the mesenchyma. At the last course of the disease the parenchyma of these organs became atrophy, degenerated and necrosed. Besides those mentioned above, the lesions of intestinal villi were also observed through the scanning electron microscope and the ultrastructural changes of liver were studied through the transmission electron microscope.
出处
《江苏农学院学报》
CSCD
1989年第1期27-32,69-70,共6页
Jiangsu Agricultural Research
关键词
小鹅瘟
病理形态学
超微结构
gosling plague
pathomorphologicay
ultrastructure
