摘要
目的:研究粪菌移植联合乳果糖对顽固性功能性便秘患者胃肠功能、生活质量及心理状态的影响。方法:选取2016年6月至2018年5月我院消化内科收治的顽固性功能性便秘患者100例为研究对象,按照随机数字表法将患者分为对照组(n=45)和研究组(n=55)。对照组给予乳果糖口服治疗,研究组则采用粪菌移植联合乳果糖治疗,两组均治疗6周。对比两组临床疗效、胃肠功能以及治疗前后生活质量和心理状态的变化,并观察两组治疗期间不良反应发生情况。结果:与对照组比较,研究组总有效率明显升高(P<0.05)。研究组首次自主排便时间、肛门首次排气时间、肠鸣音恢复时间均短于对照组,胃肠减压引流量高于对照组(P<0.05)。治疗6周后,两组患者生活质量自评量表(PAC-QOL)评分、Zung焦虑自评量表(SAS)评分和抑郁自评量(SDS)评分均较治疗前降低,且与对照组比较,研究组PAC-QOL评分、SAS评分、SDS评分均降低(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:粪菌移植联合乳果糖对顽固性功能性便秘具有较好的疗效,可改善患者胃肠功能和心理状态,同时可提高患者生活质量,无严重不良反应发生。
Objective: To study the effects of fecal microbiota transplantation combined with lactulose on gastrointestinal function,quality of life and psychological status in patients with intractable functional constipation. Methods: 100 patients with intractable functional constipation who were treated at Gastroenterology Department of our hospital from June 2016 to May 2018 were selected as the research subjects. They were divided into control group(n=45) and study group(n=55) according to random number table method.The control group was given lactulose orally, while the study group was treated with fecal bacteria transplantation combined with lactulose, and the two groups were treated for 6 weeks. The clinical efficacy, gastrointestinal function and the changes of quality of life and psychological status before and after treatment were compared between the two groups. The adverse reactions of the two groups during treatment were also observed. Results: Compared with the control group, the total effective rate of the study group was significantly higher(P<0.05). First self defecation time, anus first exhaust timet and the recovery time of bowel sounds of the study group were shorter than those of the control group, and gastrointestinal decompression flow rate was higher than that of the control group(P<0.05). After treatment, the scores of patients assessment of constipation quality of life(PAC-QOL), Zung’s self-rating Anxiety scale(SAS)and self-rating depression scale(SDS) of the two groups were lower than those before treatment, and compared with the control group,the scores of PAC-QOL, SAS and SDS in the study group were significantly decreased(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P >0.05). Conclusion: Fecal microbiota transplantation combined with lactulose has a good effect on intractable functional constipation.It can improve gastrointestinal function and mental state of patients, it can improve the quality of life of patients, and it has no serious adverse reaction.
作者
杜三军
高会斌
沈金库
李多
吴娜
DU San-jun;GAO Hui-bin;SHEN Jin-ku;LI Duo;WU Na(Department of Gastroenterology,The First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei,075000,China)
出处
《现代生物医学进展》
CAS
2019年第1期129-132,51,共5页
Progress in Modern Biomedicine
基金
河北省医学科学研究重点项目(20180831)
关键词
粪菌移植
乳果糖
顽固性功能性便秘
胃肠功能
生活质量
心理状态
Fecal microbiota transplantation
Lactulose
Intractable functional constipation
Gastrointestinal function
Quality of life
Psychological state
