摘要
目的:探讨脑梗死患者血清中五聚素3(PTX-3)、甲壳质酶蛋白40(YKL-40)和白细胞分化抗原36(CD_(36))的表达特征,分析其临床意义及相关性,以期为临床工作提供支持。方法:收集97例急性脑梗死患者作为观察组,留取空腹血清,收集无明显器质性病变的成人血清标本32例作为对照组。应用酶联免疫吸附实验检测两组中PTX-3、YKL-40和CD_(36)的表达量,并进行统计学分析。结果:两组血清中PTX-3、YKL-40和CD_(36)的表达差别有统计学意义,观察组血清中PTX-3、YKL-40和CD_(36)的表达与梗死体积、病变严重程度及是否伴有高血压病密切相关,线性相关分析显示观察组中PTX-3和YKL-40的表达呈正相关性,其它指标间均未见明显相关性。结论:急性脑梗死患者血清中PTX-3、YKL-40和CD_(36)高表达,与病变的严重程度有关,也与患者是否伴有高血压有关,PTX-3和YKL-40具有协同正向作用。
Objective:To detect the expressions of PTX-3, YKL-40 and CD36, and investigate clinical significance and relationship in patients with cerebral infarction.Methods:The study included 97 acute cerebral infarction as observation group, 32 normal adult serum as control group. Expressions of PTX-3, YKL-40 and CD36 were detected by IHC methods in two groups.Results: Expressions of PTX-3, YKL-40 and CD36 were statistical significant in two groups. Expressions of PTX-3, YKL-40 and CD36 were correlated with infarct volume, severity and hypertension. There was positive relationship between PTX-3 and YKL-40 by linear correlation.Conclusion:The higher expressions of PTX-3, YKL-40 and CD36 are found in cerebral infarction, are correlated with hypertension. Positive synergistic effect of PTX-3 and YKL-40 can promote the occurrence and development in acute cerebral infarction.
作者
杨文海
宁显忠
赵德福
赵冬凤
刘强
YANG Wenhai;NING Xianzhong;ZHAO Defu(Department of Neurology,the Third Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000)
出处
《陕西医学杂志》
CAS
2019年第3期301-303,共3页
Shaanxi Medical Journal
基金
辽宁省科技厅科研项目(2013022021)
