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多种肿瘤标志物的联合检测对宫颈癌诊断及预后判断的临床价值 被引量:9

Clinical Value of Combined Dtection of Multiple Tumor Markers on the Diagnosis and Prognosis of Cervical Cancer
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摘要 目的探讨多种肿瘤标志物的联合检测对宫颈癌的诊断及预后判断中的临床价值。方法将以已经确诊的100例宫颈癌患者作为实验组,以同期体检的100例健康妇女作为对照组,分别采用化学发光法检测两组患者中鳞状细胞癌抗原SCC,CA19-9,CA125以及CEA的水平。结果各个肿瘤标志物的水平实验组明显高于对照组,而且其还与宫颈癌临床分期和病理分化程度相关(P<0.05)。结论 SCC、CA19-9、CA125以及CEA等肿瘤标志物的联合检测,对宫颈癌的诊断以及预后判断,具有一定辅助价值。 Objective To investigate the clinical value of combined detection of multiple tumor markers on the diagnosis and prognosis of cervical cancer .Methods 100 patients with cervical cancer was the experimental group ,and 100 healthy women was the control group ,SCC antigen,CA19-9,CA125 and CEA levels of the 2 groups were detected by chemiluminescent method . Results Multiple tumor markers levels in the experimental group were higher than that of the control group ,and they were relat-ed with clinical stage and pathological degree of differentiation in cervical cancer (P<0.05).Conclusion Combined detection of SCC,CA19-9,CA125,CEA and other tumor markers can help in the diagnosis and prognosis of cervical cancer ,and has clinical value.
作者 苏晶 苏广龙
出处 《实用癌症杂志》 2014年第9期1089-1090,1104,共3页 The Practical Journal of Cancer
关键词 肿瘤标志物 宫颈癌 诊断 预后判断 Tumor markers Cervical cancer Diagnosis Prognosis
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  • 1Duffy MJ.Evidence for the clinical use of tumor markers.Ann Clin Biochem,2004,41 (Pt5):370.
  • 2Nawata S,Murakami A,Torii M,et al.Different expression patterns of intact forms of squamous cell carcinoma antigens between normal and malignant cervical squamous epithelial tissues:nondenaturing polyaorylamide gel electrophoretie analysis.Oncol Pep,2006,16(2):399.
  • 3Shimada Y,Watanabe G,Kawamura J,et al.Clinical significance of osteopontin in esophageal squamous cell carcimoma:comparison with common tumor markers.Oncology,2005,68(2-3):285.
  • 4Molina R,Fileila X,Auge JM,et al.Tumor markers (CEA,CA125,CYFRA21-1,SCC and NSE) in patients with non-small cell lung cancer as an aid in histological diagnosis and prognosis.Comparison with the main clinical aad pathological prognostic factors.Tumonr Biol,2003,24(4):209.
  • 5Ayude D,Gaoio G,et al.Combined use of established and novel tumonr markers in the diagnosis of head and neck squamous cell carcinoma.Oncol Rep,2003,10(5):1345.
  • 6Pras E,Willemas PH,Conrinus AA,et al.Serum squamous cell carcinoma antigen and CYFRA 21-1 in cervical cancer treatment.Int J Radiat Oncol Biol Plays,2002,52(1):23.
  • 7Takeda M,Sakuragi N,Okamoto K,et al.Preoperative serum SCC,CA125,and CA19-9 levels and lymph node status in equamous cell carcinoma of the uterine cervix.Acta Obstet Gynecol Scand,2002,81 (5):451.
  • 8Ohara K,Tanaka Y,Tsunoda H,et al.Assoesment of cervical cencer radiorespanse by serum squamons cell carcinoma antigen and magnetic resonance imaging.Obstet Gyncol,2002,100(4):781.
  • 9Molina R,Filella X,Auge JM,et al.CYFBA21-1 in patients with cervical cancor:comparison with SCC and CEA.Anticancer Res,2005,25 (3A):1765.
  • 10Yuan CC,Wang PH,Ng HT,et al.Both TPA and SCC-Ag levels are prognostic even in high-risk stage Ib-IIa cervical carcinoma as determinod by a stratification analysis.Eur J Gynancol Oncol,2002,23(1):17.

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  • 1刘馨,白艳香.血清肿瘤标志物和宫颈癌分期的相关性及其机制[J].中国老年学杂志,2014,34(11):2945-2946. 被引量:10
  • 2刘晓玲,车少敏,王文,姜缨,郑伟.血清SCC与宫颈癌生物学行为的相关性及临床意义[J].西安交通大学学报(医学版),2004,25(6):576-577. 被引量:16
  • 3Gocze K,Gombos K,Juhasz K,et al.Unique micro RNA expression profiles in cervical cancer[J].Anticancer research,2013,33(6):2561-2567.
  • 4Dasari S,Wudayagiri R,Valluru L.Cervical cancer:Biomarkers for diagnosis and treatment[J].Clinica Chimica Acta,2015,445:7-11.
  • 5Musba A T,Tanra H,Yusuf I,et al.The Effect of Dexamethasone on the Dynamics of Inflammation,Cortisol and analgesia in Lower Limb Surgery[J].J Pain Relief,2015,4(186):2.
  • 6Faber TJ,Japink D,Leers MP,et al.Activated macrophages containing tumor marker in colon carcinoma:immunohistochemical proof of a concept[J].Tumour Biol,2012,33(2):435.
  • 7Li X,Zhou J,Huang K,et al.The predictive value of serum squamous cell carcinoma antigen in patients with cervical cancer who receive neoadjuvant chemotherapy followed by radical surgery:a single-institute study[J].Plo S one,2015,10(4):e0122361.
  • 8Mabuchi S,Okazawan M,Matsuo K,et al.Impact of histological subtype on survival of patients with surgicallytreated stage IA2-ⅡB cervical cancer:Adenocarcinoma versus squamous cell carcinoma[J].Gynecol Oncol,2012,127(1):114.
  • 9林仲秋.FIGO/IGCS妇科恶性肿瘤分期及临床实践指南(四):子宫内膜癌[J].国际妇产科学杂志,2008,35(4):303-304. 被引量:39
  • 10程祝忠,任静,王闽,肖燕,杨宇洁,席晓秋,许国辉.MRI动态增强成像对宫颈癌的诊断和分期价值[J].西部医学,2011,23(4):713-715. 被引量:16

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