摘要
目的探析等离子电切术与抗雄激素联合治疗晚期前列腺癌且伴膀胱出口梗阻的临床疗效。方法入选104例伴膀胱出口梗阻的晚期前列腺癌患者,根据入院先后顺序分为2组,观察组54例采用等离子电切术与间断雄激素药物联合治疗,对照组50例仅采用等离子电切术治疗,观察并对比2组治疗前后前列腺体积、前列腺特异性抗原(PSA)、国际前列腺症状(IPSS)评分、残余尿量(RU)、最大尿流率(Qmax)及生活质量评分(QOL)的改变。结果经治疗,观察组前列腺体积(46.5±13.4)cm3显著小于对照组(57.6±13.9)cm3,PSA(1.8±0.6)μg/L显著低于对照组(2.6±0.9)μg/L,IPSS评分(12.8±3.4)分显著低于对照组(15.3±3.5)分,RU(29.6±16.4)ml显著低于对照组(46.2±18.3)ml,Qmax(19.2±4.0)ml/s显著高于对照组(16.3±3.8)ml/s,QOL评分(2.2±1.3)分显著低于对照组(2.8±1.4)分,差异均具有统计学意义(P均<0.05)。结论等离子电切术与抗雄激素联合治疗有助于提高伴膀胱出口梗阻的晚期前列腺癌的临床疗效。
Objective To discuss the clinical effect of plasma electric resection combined with antiandrogen for ad -vanced prostate cancer with bladder outlet obstruction ( BOO) .Methods 104 patients with advanced prostate cancer with BOO were divided into 2 groups according to admission order .The observation group (54 cases) was treated with plasma electric resec-tion combined with intermittent antiandrogen ,and the control group (50 cases)was treated with plasma electric resection .Size and PSA of prostate,IPSS,RU,Qmax and QOL changes before and after treatment of the 2 groups were observed and compared .Re-sults After treatment,size of prostate in the observation group was (46.5 ±13.4) cm3 ,obviously smaller than that of the control group (57.6 ±13.9) cm3;PSA was (1.8 ±0.6) μg/L,obviously lower than that of the control group (2.6 ±0.9) μg/L;IPSS was (12.8 ±3.4),obviously obviously lower than that of the control group (15.3 ±3.5);RU was (29.6 ±16.4) ml,obviously lower than that of the control group (46.2 ±18.3) ml;Qmax was (19.2 ±4.0) ml/s,obviously higher than that of the control group (16.3 ±3.8) ml/s;QOL was (2.2 ±1.3),obviously lower than that of the control group (2.8 ±1.4) (all P<0.05). Conclusion Plasma electric resection combined with antiandrogen can improve the efficacy of advanced prostate cancer with BOO.
出处
《实用癌症杂志》
2014年第10期1279-1281,共3页
The Practical Journal of Cancer
关键词
雄激素
等离子电切术
膀胱出口梗阻
前列腺癌
Androgen
Plasma electric resection
Bladder outlet obstruction(BOO)
Prostate cancer
