摘要
目的探讨自体骨与同种异体骨混合移植治疗四肢恶性骨肿瘤的疗效。方法回顾性分析80例四肢恶性骨肿瘤患者的临床资料,按照移植材料不同分为两组各40例,观察组采用自体骨与同种异体骨混合移植治疗,对照组采用自体骨与人造移植物混合移植治疗,比较两组临床疗效。结果观察组治疗优良率[55.0%(22/40)]显著高于对照组[32.5%(13/40)],术后骨性愈合时间[(14.5±2.2)个月]显著低于对照组[(16.2±2.6)个月],并发症发生率[47.2%(17/36)]显著低于对照组[75.0%(24/32)],差异均具有统计学意义(P均<0.05);观察组治疗满意率[77.5%(31/40)]高于对照组[65.0%(26/40)],差异不具有统计学意义(P>0.05);观察组5年生存率[75.0%(27/36)]显著高于对照组[46.9%(27/36)],差异具有统计学意义(P<0.05)。结论自体骨与同种异体骨混合移植治疗四肢恶性骨肿瘤临床疗效显著,有助于提高治疗优良率和满意率,加速骨性愈合,减少并发症发生风险并提高长期预后。
Objective To study the clinical effect of autogenous bone combined with allogeneic bone for limbs malignant bone tumors. Methods Clinical data of 80 patients with limbs malignant bone tumors were retrospectively analyzed. They were divided into 2 groups according to different transplantation materials,each with 40 cases. The observation group was treated with autogenous bone combined allogeneic bone,while the control group was treated with autogenous bone combined artificial transplant. Clinical effects of the 2 groups were compared. Results Excellent rate of the observation group was 55. 0%( 22 /40),which was obviously higher than that of the control group 32. 5%( 13 /40),postoperative bony union time of the observation group was( 14. 5 ± 2. 2) months,which was obviously shorter than that of the control group( 16. 2 ± 2. 6) months,complication rate of the observation group was 47. 2%( 17 /36),which was obviously lower than that of the control group 75. 0%( 24 /32)( all P <0. 05). Satisfaction rate of the observation group was 77. 5%( 31 /40),which was higher than that of the control group 65. 0%( 26 /40),there had no statistical difference( P > 0. 05),5-year survival rate of the observation group was 75. 0%( 27 /36),which was obviously higher than that of the control group 46. 9%( 27 /36),there had statistical difference( P < 0. 05). Conclusion Autogenous bone combined with allogeneic bone for limbs malignant bone tumors is effective. It can improve excellent and satisfaction rate,and prognosis,accelerate bony union,and reduce risks of complications.
出处
《实用癌症杂志》
2015年第6期824-827,共4页
The Practical Journal of Cancer
关键词
自体骨
同种异体骨
骨肿瘤
疗效
Autogenous bone
Allogeneic bone
Bone tumor
Clinical effect
