摘要
目的探讨乳腺腔镜经腋下小切口行乳腺癌保乳术对早期乳腺癌患者术后基质金属蛋白酶-9(MMP-9)、癌胚抗原(CEA)水平变化的影响。方法选取66例早期乳腺癌患者,随机数字表法分为对照组与研究组,各33例。对照组采用乳腺癌改良根治术,研究组采用乳腺腔镜经腋下小切口行乳腺癌保乳术。结果研究组手术用时、术中失血量、住院时间少于对照组,差异有统计学意义(P <0. 05);两组乳房美观优良率比较,研究组93. 94%(31/33)高于对照组63. 64%(21/33),差异有统计学意义(P <0. 05);术后两组血清MMP-9及CEA水平较术前降低,且研究组低于对照组,差异有统计学意义(P <0. 05);研究组并发症发生率[9. 09%(3/33)]低于对照组[33. 33%(11/33)],差异有统计学意义(P <0. 05)。结论采用乳腺腔镜经腋下小切口行乳腺癌保乳术治疗早期乳腺癌效果显著,可减少手术用时及失血量,降低血清MMP-9及CEA水平,提高乳房美观效果,且并发症发生率较低。
Objective To investigate the effect of mammary glandoscopic ultrasonography on the expression of matrix metalloproteinase-9( MMP-9) and carcinoembryonic antigen( CEA) in patients with early breast cancer. Methods 66 patients with early breast cancer in XX hospital were randomly divided into control group and study group,33 cases each group. The control group was treated with modified radical mastectomy for breast cancer. The study group was treated with breast cavity endoscopic ultrasonography. Surgical condition( intraoperative blood loss,hospitalization time),breast aesthetic effect,serum MMP-9 and CEA levels and complications fo the two groups before and after surgery were compared. Results The operative time,intraoperative blood loss and hospital stay of the study group was less than that of the control group,the difference was statistically significant( P < 0. 05);The excellent and good rate of breast in the study group( 93. 94%,31/33) was higher than that in the control group( 63. 64%,21/33),the difference was statistically significant( P < 0. 05);The levels of serum MMP-9 and CEA in the two groups after operation were lower than those before operation,and the difference was statistically significant( P < 0. 05);The incidence of complications in the study group was 9. 09%( 3/33) lower than that in the control group( 33. 33%,11/33),the difference was statistically significant( P < 0. 05). Conclusion The use of breast cavity endoscopic breast cancer underwent breast cancer breast conserving surgery in the treatment of early breast cancer gets significant effect,it can reduce the time and blood loss of surgery,reduce serum MMP-9 and CEA levels,improve breast aesthetic effect,and the incidence of complications low.
作者
王文胜
张双林
马志强
李帅
吴海滨
张筱杨
张冠男
WANG Wensheng;ZHANG Shuanglin;MA Zhiqiang(The First Affiliated of Henan University,Kaifeng,475000)
出处
《实用癌症杂志》
2019年第3期374-377,共4页
The Practical Journal of Cancer
关键词
乳腺腔镜
经腋下小切口
乳腺癌保乳术
早期乳腺癌
MMP-9
CEA
Breast cavity mirror
By axillary incision
Breast cancer breast conserving surgery
Early breast cancer
MMP-9
CEA
