摘要
目的探讨α-硫辛酸对糖尿病肾病患者尿足细胞标志蛋白(PCX)水平及血清血管内皮生长因子(VEGF)水平的影响。方法选取2011年1月—2014年8月苏州市吴中人民医院收治的糖尿病肾病患者118例,采用随机数字表法分为对照组58例和观察组60例。对照组患者给予常规治疗,观察组患者在常规治疗基础上加用α-硫辛酸,治疗2周。比较两组患者治疗前后空腹血糖(FBG)、糖化血红蛋白(HbA_(1c))、收缩压、舒张压、总胆固醇、三酰甘油、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、肌酐、尿素氮、尿PCX水平及血清VEGF水平。结果两组患者治疗前FBG、HbA_(1c)、收缩压、舒张压、总胆固醇、三酰甘油、LDL-C、HDL-C、肌酐、尿素氮、尿PCX水平及血清VEGF水平比较,差异均无统计学意义(P>0.05)。观察组患者治疗后FBG、HbA_(1c)、总胆固醇、三酰甘油、LDL-C、肌酐、尿素氮、尿PCX水平及血清VEGF水平均低于对照组,HDL-C高于对照组(P<0.05);而两组患者治疗后收缩压、舒张压比较,差异无统计学意义(P>0.05)。结论α-硫辛酸可有效降低糖尿病肾病患者尿PCX水平及血清VEGF水平。
Objective To explore the influence of alpha lipoic acid on urine podocalyxin level and serum vascular endothelial growth factor( LVEF) level of patients with diabetic nephropathy. Methods A total of 118 patients with diabetic nephropathy were selected in Wuzhong People's Hospital of Suzhou from January 2011 to August 2014,and they were divided into control group( n = 58) and observation group( n = 60) according to random number table. Patients of control group received conventional treatment, while patients of observation group received alpha lipoic acid based on conventional treatment; both groups continuously treated for two weeks. FBG,HbA_(1 c),systolic blood pressure,diastolic blood pressure,total cholesterol,triglycerides,LDL-C,HDL-C,creatinine,urea nitrogen,urine PCX level and serum VEGF level were compared between the two groups. Results Before treatment, no statistically significant differences of FBG, HbA_(1c), systolic blood pressure,diastolic blood pressure, total cholesterol, triglycerides, LDL-C, HDL-C, creatinine, urea nitrogen, urine PCX level or serum VEGF level was found between the two groups( P > 0. 05). After treatment, FBG, HbA_(1c), total cholesterol,triglycerides,LDL-C,creatinine,urea nitrogen,urine PCX level and serum VEGF level of observation group were statistically significantly lower than those of control group,HDL-C of observation group was statistically significantly higher than that of control group( P < 0. 05),while no statistically significant differences of systolic blood pressure or diastolic blood pressure was found between the two groups( P > 0. 05). Conclusion Alpha lipoic acid can reduce urine podocalyxin level and serum LVEF level of patients with diabetic nephropathy.
出处
《实用心脑肺血管病杂志》
2016年第5期148-150,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
