摘要
目的介绍近些年钯催化剂的发展历程及不同类型钯催化剂在潜手性胺类化合物的动态动力学拆分(dynamic kinetic resolution,DKR)中的具体应用。方法通过总结近年来钯催化剂在动态动力学拆分中应用的相关文献,从催化条件及反应结果等方面对其进行综述。结果阐明了钯催化剂在DKR反应中的催化条件和反应结果,总结了钯催化剂的研究过程并重点介绍了其最新的研究进展。结论钯催化剂是DKR过程中一种重要的催化剂,具有很好的的应用前景。
Objective To introduce the development of palladium catalysts in recent years and the application of different kinds of palladium catalysts in the dynamic kinetic resolution( DKR) of prochiral amines.Methods Based on the catalytic conditions and the results,recently published papers about palladium catalysts were reviewed. Results The catalytic conditions and the results of palladium catalysts in DKR were elucidated;the development of palladium catalyst and its recent achievement were introduced. Conclusion The palladium catalyst is important in DKR,which is of broad prospects in the manufacture of pharmaceutical.
作者
孙仲桥
孟令新
贾娴
SUN Zhongqiao;MENG Lingxin;JIA Xian(School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,China)
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2018年第12期1084-1088,共5页
Journal of Shenyang Pharmaceutical University
基金
教育部科学技术基金(213007A)
国家基础科学人才培养基金资助(J1103606)
关键词
动态动力学拆分
钯催化剂
手性化合物
dynamic kinetic resolution(DKR)
palladium catalysts
chiral amines
