摘要
[目的]观察益气活血通络汤联合西药治疗缺血性脑卒中(气虚血瘀)疗效。[方法]使用随机平行对照方法,将66例住院患者按病志号抽签方法随机分为两组。对照组33例胞磷胆碱0.5g,舒血宁20mL+0.9%氯化钠250mL,1次/d,静滴。治疗组33例益气活血通络汤(黄芪30g,鸡血藤、当归、丹参各15g,桃仁12g,红花、川芎、甘草炙、地龙各10g,水蛭3g),水煎500mL,2次/d;西药治疗同对照组。连续治疗14d为1疗程。观测临床表现、神经运动功能(Fugl-Meyer法)、Barthes指数、TNF-α、CRP、IL-6、日常生活能力、神经功能缺损、不良反应。治疗1疗程(14d),判定疗效。[结果]神经运动功能、Barthel指数、TNF-α、CRP、IL-6、日常生活能力、神经功能缺损、全血中切黏度、全血高切黏度、血浆黏度、红细胞比容、红细胞沉降率两组均有改善(P<0.01),全血低切黏度对照组无显著变化(P>0.05),治疗组显著降低(P<0.05),神经运动功能、Barthel指数、TNF-α、CRP、IL-6、ADL、NIHSS、全血低切黏度、全血中切黏度、全血高切黏度、血浆黏度、红细胞比容、红细胞沉降率治疗组改善优于对照组(P<0.01),红细胞沉降率两组无明显差异(P>0.05)。[结论]益气活血通络汤联合西药治疗缺血性脑卒中(气虚血瘀),疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Yiqi Huoxue Tongluo decoction combined with western medicine on ischemic stroke(Qixu Xueyu). [Method] Sixty-six inpatients were randomly divided into two groups by drawing lots according to the disease sign by random parallel control method. In the control group, 33 cases of citicoline 0.5 g, Shuxuening 20 mL+0.9% sodium chloride 250 mL, once a day, intravenous drip. The treatment group consisted of 33 cases of Yiqi Huoxue Tongluo decoction(Huangqi 30 g, Jixueteng,Danggui, Danshen each 15 g, Taoren 12 g, Honghua, Zhigancao, Dilong each 10 g, Shuizhi 3 g), decocted500 mL, twice a day;western medicine treatment was the same as the control group. Continuous treatment for14 days is a course of treatment. Clinical manifestations, neuromotor function(Fugl-Meyer method), Barthes index, TNF-α, CRP, IL-6, daily living ability, neurological deficits and adverse reactions were observed.One course of treatment(14 days) was used to determine the curative effect. [Result] Neuromotoxic function,Barthel index, TNF-α, CRP, IL-6, daily living ability, nerve function defect, whole blood shear viscosity,whole blood high shear viscosity, plasma viscosity, erythrocyte specific volume and erythrocyte sedimentation rate were improved in both groups(P<0.01). There was no significant change in whole blood low shear viscosity control group(P>0.05). The treatment group decreased significantly(P<0.05). Neuromotoxic function, Barthe whole blood high shear viscosity, plasma viscosity, erythrocyte sedimentation rate were improved in both groups(P The improvement of L index, TNF-α, CRP, IL-6, ADL, NIHSS, whole blood low shear viscosity, whole blood medium shear viscosity, whole blood high shear viscosity, plasma viscosity,erythrocyte specific volume and erythrocyte sedimentation rate in the treatment group were better than those in the control group(P<0.01), and there was no significant difference in erythrocyte sedimentation rate between the two groups(P>0.05). [Conclusion] Yiqi Huoxue Tongluo decoction combined with western medicine in the treatment of ischemic stroke(Qi deficiency and blood stasis) has satisfactory curative effect and no serious adverse reactions, which is worthy of promotion.
作者
万圆圆
陈杨磊
王讯
WAN Yuanyuan;CHEN Yanglei;WANG Xun(Dongtai Traditional Chinese Medicine Hospital,Encephalopathy Department,Dongtai 224200,Jiangsu,China;Dongtai Traditional Chinese Medicine Hospital,Ophthalmology Department,Dongtai 224200,Jiangsu,China;Dongtai Traditional Chinese Medicine Hospital,Otolaryngology Head and Neck Surgery,Dongtai 224200,Jiangsu,China)
出处
《实用中医内科杂志》
2018年第12期24-27,共4页
Journal of Practical Traditional Chinese Internal Medicine
