摘要
槲皮素广泛存在于双子叶植物的根、茎、叶中。槲皮素具有较好的止咳平喘的作用,对心血管疾病也有较好的治疗作用,如降血压、降血脂、抗动脉粥样硬化、抗心肌缺血、扩张冠状动脉、增加冠状动脉血流量等。然而,槲皮素的水溶性极低,具有口服吸收差,生物利用度低的缺点。文章总结了槲皮素对心血管系统疾病的影响,并对其新剂型进行概述,以期为槲皮素的进一步研究与开发提供参考。
Quercetin was found in the roots,stems and leaves of dicotyledonous plants.It has the pharmacological effects of relieving cough and relieving asthma and treating cardiovascular diseases,such as lowering blood pressure,lowering blood lipid,anti-atherosclerosis,anti-myocardial ischemia,dilating coronary artery,increasing coronary blood flow,etc.However,quercetin has the disadvantages of low water solubility,poor oral absorption,low bioavailability,etc.The article summarizes the effect of quercetin on cardiovascular diseases and summarizes its new dosage form,aimed to provide references for the further research and development of quercetin.
作者
陈振华
胡晓艳
赵滕
许泉
王静
熊印华
周斌
CHEN Zhen-hua;HU Xiao-yan;ZHAO Teng;XU Quan;WANG Jing;XIONG Yin-hua;ZHOU Bin(Jiangxi Science and Technology Normal University,Nanchang 330013,China;Jiangxi Province Key Laboratory of Drug Design and Evaluation,Nanchang 330013,China)
出处
《时珍国医国药》
CAS
CSCD
北大核心
2019年第2期440-443,共4页
Lishizhen Medicine and Materia Medica Research
基金
国家自然科学基金(81703716)
江西省教育厅科技项目(GJJ160800)
江西科技师范大学研究生创新专项资金项目(YC2018-X28)
关键词
槲皮素
心血管
剂型
Quercetin
Cardiovascular
Dosage form
