摘要
目的:探讨植入血管的变性骨骼肌桥接面神经缺损的新方法。方法:以40只日本大耳白兔左侧面神经上颊支缺损10mm为模型,按随机数字表法分A、B两组,A组用血管植入的自体变性骨骼肌修复,B组作为对照用自体神经移植修复。结果:术后6个月电生理检测:A组神经干复合动作电位(NAP)(920±436)μV,振幅积分(NAPA)(0.79±0.14)mV·ms,而B组NAP(1103±486)μV,NAPA(0.93±0.26)mV·ms,两组比较差异无显著性(P>0.05);A组神经传导速度(NCV)(32.6±4.3)m/s,而B组NCV(42.5±5.7)m/s,两组比较差异有显著性(P<0.01)。肌桥中段再生神经纤维图像分析:A组神经纤维总数(4042±719)条和神经纤维密度(15.2±1.9)%,B组相应指标分别是(4481±689)条和(16.4±2.1)%,两组比较差异亦无显著性(P>0.05)。结论:血管植入自体变性骨骼肌可有效引导神经再生并修复面神经缺损。
AIM:To explore the new method of repairing facial nerve defect by implanting autologous degenerative skeletal muscle into vessels. METHODS:The 10 mm defects of left sidedness bucal branch of facial nerve obtained from 40 Japanese flap eared rabbits were as models. The rabbits were divided into A and B groups at random with digital table methods. The defects were repaired by autologous degenerative skeletal muscles planted into vessels in the A group. The defects were repaired by autologous nerves in the B group as controls. RESULTS:In the electrophysiologic examining after 6 months following repair: Nerve action potential(NAP) was (920± 436) μ v and the nerve action potential amplitude (NAPA)was (0.79± 0.14) mv· ms in the A group, and NAP was(1 103± 486) μ v and NAPA was(0.93± 0.26) mv· ms in the B group. The difference between the two groups had no statistical significance (P >0.05). Nerve circulate velocity(NCV)was (32.6± 4.3)m/s and(42.5± 5.7)m/s in the two groups respectively, with a significant difference (P< 0.01). In the analysis of graph of regenerative neurofibers in middle part of muscle bridge: The total amount of the regenerative neurofibers was (4 042± 719)s and its density was (15.2± 1.9)% in the A group, and corresponding indices were (4 481± 689) s and (16.4± 2.1)% respectively in the B group, and no significant difference was found between the two groups (P >0.05).
出处
《中国临床康复》
CSCD
2003年第23期3172-3173,T001,共3页
Chinese Journal of Clinical Rehabilitation
关键词
血管植入
变性骨骼肌
修复
面神经缺损
实验研究
The results indicated that the autologous degenerative skeletal muscle planted into vessels effectively guides facial nerve regeneration and finely repairs 10mm defect of facial nerve.
