摘要
目的 :探索对阿尔茨海默病 (AD)病人认知和记忆能力具有明显改善作用的中药方剂。方法 :通过Balb/c小鼠侧脑室微量注射聚集态 β 淀粉样多肽 (β AP2 5 35) ,建立模拟AD的小鼠动物模型 ,并通过行为学实验和脑组织组织化学检测 ,研究了中医经典药方柴胡加龙骨牡蛎汤、当归芍药散和作者自己研制的两种中药复方CHPI和CHPⅡ对该小鼠模型认知和记忆能力的疗效作用。同时 ,以西药脑复康做对照。结果 :CHPⅡ对AD模型小鼠的认知和记忆能力具有明显的改善。结论
Objective: To investigate Chinese herbs with the effect on significantly improving the cognitive function and retention of patients with Alzheimer's disease. Method: AD mouse models were established by injecting poly β AP 25 35 into the cerebral ventricle of mice. The curative effects of traditional Chinese herbs Dangguishaoyaosan, Chaihujialonggumulitang and two herbs (CHP Ⅰ and CHP Ⅱ) developed by the authors on improving the memory and cognitive function of AD mouse models were studied by the detection of behavioral and histochemical tests, with piracetam serving as control. Result: CHP II has profound curative effects on improving the memory and cognitive function of AD like animal model. Conclusion: The present study indicates that it has a satisfactory prospect to seek new drugs from Chinese herbs to treat AD.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2003年第8期751-754,共4页
China Journal of Chinese Materia Medica
基金
美国中华医学基金会 (CMB)资助 ( 99 6 99)
