摘要
应用放射免疫测定法分别对健康人、急性白血病病人血清与骨髓细胞内β_2微球蛋白含量变化进行了观察,并同时对正常人外周血淋巴细胞进行体外培养,检测其培养液上清液的β_2微球蛋白水平.结果表明,急性白血病病人治疗前及复发时血清β_2微球蛋白明显升高,完全缓解时下降至正常.同期骨髓单个核细胞内β_2微球蛋白(BM-β_2M)含量正常,与血清β_2微球蛋白(S-β_2M)升降无关.经植物血凝素(PHA)刺激后的淋巴细胞产生β_2微球蛋白明显增加.提示急性白血病S-β_2M升高与白血病细胞本身无直接相关,可能与淋巴细胞合成的β_2微球蛋白增多有关.
The concentration of Beta 2 microglobulin (β_2M)in serum and in bone marrow cells from normal persons and patients with acute leukemia (AL) was measured by radioimmunossay, and its variation in different clinical periods was observed. The concentration of β_2M in super liquid from normal lymphocytic cells that had been cultured was also examined. The results showed that the concentration of serum Beta 2 microglobulin (Sβ_2M) in AL was significantly elevated in untreated patients and patients with relapse as compared with that in normal persons, and it reverted to normal level when the patients were in complete remission. The level of β_2M within bone marrow cells (BM-β_2M) was normal. There was no relation between the level of S-β_2M and that of BN-β_2M . β_2M pro
duced by normal lymphocytic cells that were stimulated by phytohemagglutinin(PHA) was significantly elevated. The results suggest that the increase of S-β_2M is not directly related to the leukemic cells themselves, but is probably due to the increase of S-β_2M synthesized by lymphcytic cells in AL.
出处
《青岛医学院学报》
1992年第4期307-309,共3页
Acta Academiae Medicinae Qingdao Universitatis
关键词
白血病
微球蛋白
骨髓细胞
leukemia
beta 2 microglobulin
bone marrow cells
radioimmunossay
