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肾移植后不同免疫抑制剂的应用研究 被引量:3

The Effects of Different Immunosuppressants on Renal Transplantation
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摘要  目的 :分析肾移植后不同的免疫抑制用药方案对移植效果、副作用及长期存活的影响。方法 :根据不同用药组合将 2 0 1例患者分为环孢素A(CsA)、硫唑嘌呤 (Aza)、强的松 (Pred)三联治疗组 ,CsA、霉酚酸酯 (MMF)、Pred三联治疗组 ,CsA和Pred二联治疗组 ,Aza和Pred传统二联治疗组 ,统计分析 4组患者排斥反应和肾存活情况。结果 :三联治疗组 1、3、5年存活率高于传统二联治疗组 ,排斥反应发生率也明显降低。结论 :肾移植后三联治疗组早期急性排斥反应发生率明显低于二联治疗组。 Objective: To analyze the influence of different combinations of immunosuppressants on therapeutic effects, side effects and long term survival. Methods: According to different combinations of immunosuppressants, 201 cases are divided into four groups: (1) cyclosporine (CsA), azathioprine(Aza) and prednisolone; (2) cyclosporine, mycophenolate mofetil (MMF) and prednisolone (Pred); (3) cyclosporine, and prednisolone; (4) cyclosporine and azathioprine. The rejection frequency and the survival of kidneys were investigated, and statistical analysis was made. Results: Those treated with three drugs had a much higher survival rate and a much lower rejection rate than those with two drugs in 1 year, 3 years and 5 years periods. Conclusion: Renal transplant recipients treated with CsA, Aza and Pred have a much lower acute rejection frequency than those treated with Aza and Pred in the early period.
出处 《海军医学杂志》 2003年第3期196-198,共3页 Journal of Navy Medicine
关键词 肾移植 免疫抑制剂 排斥反应 用药方案 renal transplantation immunosuppressants rejection
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参考文献2

  • 1[1]PIRSCH J D, MILLER J, DEIERHOI M H, et, al. A comparison of tacrolimus and cycloporine for immunosuppression after cadaveric renal transplantation[J]. Transplantation, 1997, 63: 977-983.
  • 2[2]OPELZ G. Superior long-term kidney graft survival in patient on maintenance immunosuppression with cyclosporine and azathioprine[J]. Tansplant Pioc, 1993, 25: 1 289-1 290.

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