摘要
目的 探讨硫氧还蛋白还原酶在大鼠心肌抗氧化应激反应中的作用。方法 将 Wistar大鼠冰泳 5min,采用 Northern blot和 Western blot检测大鼠冰泳前后心肌硫氧还蛋白还原酶的表达情况。结果 应激后大鼠心肌中硫氧还蛋白还原酶的基因和蛋白表达均增加。
Objective To study the role of thioredoxin reductase against oxidative stress in myocardia in rats.Methods We let wistar rats swim in ice water for five minutes,then detected the effects of oxidative stress on thioredoxin reductase in myocardia with Northern blot and Western blot.Results After stress the expression of protein and gene of thioredoxin reductase in rat myocardia were measurably increased.Conclusions The increased expression of thioredoxin reductase may resist oxidative stress and prevent myocardia from being injured.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2003年第5期392-393,共2页
Chinese Jouranl of Endemiology
