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肿瘤新生血管抑制剂——血管抑素和内皮抑素 被引量：6

Tumor Neoangiogenesis Inhibitors——Angiostatin and Endostatin Implication
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摘要 血管抑素和内皮抑素是两种内源性肿瘤新生血管抑制剂,主要通过抑制肿瘤内皮细胞的生长达到抑制肿瘤血管生成、诱导肿瘤细胞凋亡、防止肿瘤侵袭和转移的目的。作为两种最有前途的肿瘤新生血管抑制剂克服了肿瘤化疗过程中产生的耐药抗药性。文中对这两种抑制剂的结构与功能及应用研究最新进展作一综述。 Angiostatin and endostatin are two tumor neoangiogenesis inhibitors . They can suppress the growth of endothelial cell of the newly formed blood vessels in tumor , induce apoptosis and prevent tissue invasion,metastasis.Patients do not become resistant to angiostatin and endostatin despite continued treatment as chemotherapies proceed.The paper explains angiostatin and endostatin structure,fuction through schemic diagrams,and reviews their implications from the latest progress.
作者 吴扬兰 王远亮
机构地区 重庆大学生物工程学院生物力学及组织工程教育部重点实验室
出处 《重庆大学学报（自然科学版）》 EI CAS CSCD 北大核心 2003年第10期72-75,共4页 Journal of Chongqing University
基金 国家自然科学基金资助(30270395)
关键词 血管抑素 内皮抑素 肿瘤新生血管 结构与功能 肿瘤治疗 angiostatin endostatin neoangiogenesis inhibitors structure and fuction cancer therapy
分类号 TG146 [金属学及工艺—金属材料]
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参考文献17

  • 1李福洋,何鹏,刘新平,张英起,杨静华,樊代明,药立波,fmmu.edu.cn.一步法从人血浆中制备天然血管生成抑制素[J].生物化学与生物物理进展,2000,27(3):325-327. 被引量：10
  • 2杨辉,张英起,颜真,韩苇,药立波,苏成芝.人血管生成素cDNA的克隆与表达[J].中国生物化学与分子生物学报,2000,16(4):473-477. 被引量：4
  • 3陈飞虎,智强,杨军.肿瘤治疗新思路——抗血管生成来治疗实体瘤[J].医学与哲学,1999,20(9):40-41. 被引量：1
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二级参考文献23

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共引文献12

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二级引证文献10

重庆大学学报（自然科学版）
2003年 第10期

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