摘要
目的 :评价放射性核素153钐 -乙二胺四甲撑酸 ( 153Sm -EDTMP)治疗恶性肿瘤骨转移的疗效和副作用 ;方法 :用153Sm -EDTMP对 1 86例骨转移的病人进行内照射治疗 ,剂量 ( 2 9.6～ 3 7.0 )MBq kg体重 ,观察治疗前后骨痛、血清碱性磷酸酶 (ALP)、血细胞及病灶的变化 ;结果 :1 86例病人中 1 54例 ( 82 .8% )骨痛缓解 ,随访 2 5例病人有 8例( 3 6.3 % )病人骨转移灶钙化或消除 ;治疗后病人末梢白细胞、血小板、红细胞和血红蛋白较治疗前均有显著降低 (t=8.1 9、7.3 9、5.0 0、4.1 5、P均 <0 .0 0 1 ) ;结论 :153Sm -EDTMP对转移性骨肿瘤有明显缓解骨痛、控制病情进展和消除病灶的作用 ,同时有降白细胞。
Objective:To evaluate the effects and side effects of samatium-153-ethy lenediamine tetranethylene phosphonnic acid ( 153 Sm -EDTMP)in the treatment of osseous metastasis of malignant turnors.Methods:186 patients with osseous metastasis under trentment with 153 Sm -EDTMP ranged from 29.6 to 37.0MBq/kg.the changes of bone rain,blood pictures and metstasis foci were observed before and after the treatment.Results:After treatment, 154 of 186 cases (82.8%) experienced osteodynia relief and the calcification and disappearance of metastasis foci were found in 8 of 25 to follow-up patients. The counts of WBC,PLT,RBC and Hb level decreased significantly after treatment comparied with that before treatment (t=8.19?7.39?5.00?4.15 separatly,P<0.001).Conclusion:Treatment of malignant tumor osseous metastasis using 153 Sm -EDTMP has efficiency on osteodyhid relief,metastasis foci control but induces the decreased level of WBC, RBC and Hb.
出处
《青海医药杂志》
2003年第8期26-28,共3页
Qinghai Medical Journal
