摘要
克山病是病因未明的心肌病,辅酶Q_(10)(C_0Q_(10))用于治疗克山病已有报道,并取得一定疗效,同时辅 酶Q又是细胞线粒体呼吸链的一个组分,是电子传递系统中的递氢体,是生成ATP的必须成分。为了深入开展辅酶Q代谢机制的研究,必须建立直接测定心肌组织和线粒体中辅酶Q含量的方法,否则难以研究,为此我们建立了高效液相色谱法,并获得成功。用此法开展了:(一)克山病患者心肌组织中辅酶Q_(10)含量的研究,(二)辅酶Q_(10)对损伤心肌的保护作用的研究,取得一定的结果,为临床应用提供了实验依据。
This paper reports the quantitative determination of ubiquinone content in myocardium of patients with Keshan disease. We found that the content of ubiquinone in myocardium of patients with Keshan disease was lower than that of healthy persons and their content was so lower as half of the control group. We also found that ubiquinone-10 have function to protect myocardium.
出处
《色谱》
CAS
CSCD
北大核心
1992年第2期115-117,共3页
Chinese Journal of Chromatography
