摘要
目的 观察银杏叶提取物 (简称EGb)静脉注射给药后 ,对不完全性脑缺血大鼠的保护作用 ,并探讨其抗脂质过氧化作用。方法 采用双侧颈总动脉结扎造成大鼠不完全性脑缺血模型 ;通过生化手段 ,对脑组织中与脂质过氧化有关的一些指标进行检测。结果 EGb可降低脑缺血大鼠的脑梗死区重量、脑含水量 ,增强脑组织中SOD的活性 ,减少MDA的含量 ,并可降低脑毛细血管通透性。结论 EGb对实验性大鼠脑缺血具有保护作用 ,并有抗脂质过氧化的作用。
OBJECTIVE: To study the protective effects of EGb injection on brain ischemia in rats. METHODS: The imperfectible brain ischemia model was produced in rats by occluding the double internal carotid. Some indices related to lipid peroxidation of brain tissue were measured with biochemical methods. RESULTS: The infarct size and the water content in the brain tissue with brain ischemia were reduced. It also elevated the activity of SOD and decreased the MDA contents in brain tissue. The permeability of capillary vessel was decreased. CONCLUSION: EGb can protect the injury of brain ischemia of rats. Its mechanism may be due to the anti-peroxidative function of lipid.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2003年第9期673-675,共3页
Chinese Pharmaceutical Journal
