摘要
目的 研究口腔感染与冠心病的关系。方法 比较 5 9例冠心病患者和 5 1例非冠心病患者的冠心病常见易患因素、口腔健康状况以及唾液血链球菌的可培养菌总数SSs和龈下菌斑血链球菌的可培养菌总数SSp。因SSs和SSp呈明显偏态分布 ,采用其自然对数转换值 [LN(SSs +1)、LN(SSp +1) ]进行比较。采用logistic多元逐步回归向前法分析并筛选出冠心病的危险因素。结果 单因素分析发现冠心病组患者总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL C)、牙龈炎牙数、牙周炎牙数、LN(SSp +1)均高于非冠心病组 (P <0 0 5～ 0 0 1) ;多因素分析发现仅LN(SSp +1)和LDL C与冠心病显著相关 ,前者的相对危险度为 1 438( 95 %可信区间 1 12 7～ 1 834) ,后者的相对危险度为 2 2 71( 95 %可信区间 1 2 49～ 4 12 9)。结论 口腔健康状况与冠心病密切相关 ,尤其是龈下菌斑中血链球菌菌量与冠心病独立相关。心血管医生有义务提醒患者积极去除口腔内可能存在的危险因素。
Objective To investigate the correlation of oral infections and coronary heart disease(CAD). Methods Fifty nine patients with CAD and fifty one with no CAD were compared with their traditional cardiovascular risk factors, oral health status and the amount of Streptococcus Sanguis(SS) in saliva and subgingival plaque(SSs and SSp). The natural logarithm transformation of SSs and SSp [LN(SSs+1), LN(SSp+1)] were used to analyse due to their skew distribution. The related risk factors of CAD were included in a stepwise logistic regression analysis. Results Univariate analysis showed that there was significant difference in plasma total cholesterol(TC), lower density lipoprotein cholesterol(LDL-C), the number of tooth in gingivitis, the number of tooth in peridontitis, LN(SSp+1)between patients with CAD and those with no CAD(P<0.05～0.01). Logistic regression analysis showed that LN(SSp+1) and LDL-C were strongly correlated with incidence of CAD. The relative risk were 1.438(95%CI was 1.127～1.834)and 2.271(95%CI was 1.249～4.129) respectively. Conclusion The amount of oral SS may be one of the predictors for CAD.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2003年第3期195-197,共3页
Chinese Journal of Cardiology
关键词
口腔感染
冠心病
动脉粥样硬化
链球菌
Atherosclerosis
Infection
Streptococcus, sanguis
Risk factor
