摘要
目的 观察银杏叶提取物 (EGb)治疗帕金森病 (PD)的效果 ,论证EGb治疗PD的可能性。方法 通过PD大鼠模型 ,采用免疫组织化学、HE染色、电镜及旋转行为检查的方法 ,观察模型成功后EGb(EGb组 )治疗 1天、7天、14天大鼠旋转行为及黑质病理变化 ,并与对照组 (PD组 )比较。结果 EGb组酪氨酸羟化酶染色显著高于PD组 (P <0 0 5 ) ,旋转圈数、黑质bFGF蛋白表达均较PD组减少 (均P <0 0 5 ) ,EGb组黑质超微结构及HE染色结构损伤均减轻。
Objective To observe the effect of treating Parkinson disease(PD) by Extract Ginkgo Bilobar(EGb) and demonstrate the possibility of EGb to treat PD Methods At 1d,7d,14d after PD rats model were succeded, rotational behaviour, immunohistochemistry,electronicmicroscopic were used to evaluate the role of EGb to treat PD Results On the group of EGb, the rotational behaviour and bFGF protein expression was lower,TH staining positive neurons was significantly more than the group of PD(all P <0 05).Electronicmicroscopic structure of the group of EGb were ameliorated effectively Conclusion EGb may be an effective drug to treat PD
出处
《临床神经病学杂志》
CAS
2003年第5期281-283,共3页
Journal of Clinical Neurology
基金
国家自然科学基金资助项目 (基金编号 :30 1 70 334)
