摘要
目的:探讨纳洛酮对丘脑部高血压脑出血患者运动、语言功能的促进恢复作用。方法:44例丘脑部高血压脑出血并破入脑室内患者随机分成纳洛酮组和对照组,纳洛酮组22例,每天持续静脉注射纳络酮4.8mg,同时每天从脑室引流管中分10次共注入纳洛酮4mg,连续应用10d。对照组除未用纳洛酮外,其他治疗方法皆同纳洛酮组。同时观测两组患者第1,3,7,10天的哥拉斯格昏迷评分(GCS),代表患者的意识状况,大脑中动脉(MCA)的血流速度,血液流变学变化,血糖浓度,应激性溃疡发生率,语言和运动功能评分,哥拉斯格结局评分(GOS)评分。结果:纳洛酮组的GCS评分于第7天12.12±3.05,第10天12.66±3.25明显高于对照组10.23±4.01,10.89±4.21(P<0.05);纳洛酮组第3～7天内的MCA的平均血流速度、平均全血黏稠度和红细胞变形指数皆低于对照组(P<0.05);随访2个月时的运动、语言功能评分和GOS评分纳洛酮组皆高于对照组(P<0.05);纳洛酮组第7,10的血糖浓度低于对照组较接近正常值,应激性溃疡的发病率也较对照组低。结论:早期、多途径、大剂量应用纳洛酮能有效保护脑神经功能,降低机体损伤后应激反应的程度,促进脑神经功能的恢复。
AIM:To investigate the clinical effects of naloxone in treatment of hyper-tensive cerebral hemorrhage at the s ite of thalamus area.METHODS:Forty-four patients with thalamus h ypertensive cerebral hem-orrhage were randomly assigned to re ceive the intravenous injection of naloxone at a dose of 4.8mg and the inj ection of naloxone through ventric-ular drain at a daily dose of 4mg ten times every day for ten days(n=22)or the routine treatment without naloxone for ten days(n=22).Both groups were followed up for 3months.The Gla sgow Come Scale(GCS),the speed of blood flow in middle cerebral arte ry(MCA),the changes of hemorheol-ogy,the concentration of blood suga r,the incident rate of stress ulcer a nd functional score of language and movement and the score of the Glasgow outcome scale(GOS )in both groups were compared.RESULTS:The scores of GCS in the naloxone grou p were 12.12±3.05at7days and 112.66±3.25at 10days,sig nificantly higher than those in the control group respectively(10.23±4.01and 10.89±4.21)(P<0.05).The mean speed of blood flow in MCA,th e mean blood viscosity and ery-throcyte deformity index at 3to 7days were lower than those in the control group(P<0.05).During the two-month follow-up,th e motor function,verbal function and the score of GOS w ere better than those in the control group(P<0.05).The blood sugar concentration in th e naloxone group,which was close to the normal value,was lower at 7and 10days than that in the control group.The incident rate of stress ulcer was also lower in the naloxone group as compared with the c ontrol group.
出处
《中国临床康复》
CSCD
2003年第28期3846-3847,共2页
Chinese Journal of Clinical Rehabilitation
关键词
纳洛酮
治疗
丘脑出血
运动语言功能
大脑中动脉
MCA
脑神经
Data confirm that early,all-purpose,large dose use of naloxone can effectively protect th e function of cerebral nervous syste m,decline the pathophysiological change due to post-injury stress reaction,and improve the recovery of cerebral nervo
