摘要
目的:探讨西立伐他汀与辛伐他汀对高脂血症患者的调脂作用。方法:32例高脂血症患者随机分为两组,服药前及服药4wk后测定血脂。结果:(1)服药4wk后总胆固醇(TC)水平分别降低了28.9 ％和28.0%(P<O.01),低密度脂蛋白胆固醇(LDL—C)水平分别降低了31.5％和32.5％(P<0.01);(2)西立伐他汀明显降低血清甘油三酯(TG)水平(P<0.05);(3)服用西立伐他汀和辛伐他汀4wk后脂蛋白(LPa)水平分别降低了35.3%(P<0.01)和27.8％(P<0.05)。结论:西立伐他汀能显著降低高脂血症患者血清TC和LDL-C水平,其作用与辛伐他汀相同,西立伐他汀降低TG作用优于辛伐他汀。
OBJECTIVE: To compare the hypolipidemic effects betwwen cerivastatin and simvastatin in patients with hy-pcrlipidemian. METHODS: 32 patients with hyperlipidemia were randomly divided into cerivastatin group and simvastatin group( control group) .Scrum lipid profiles were determined before and 4 weeks after treatment. RESULTS: (l)The effects of cerivastatin on lowering serum total cholesterol(TC) and low density lipoprotein cholesterol(LDL - C) levels were the same as those of simvastatin; the concentrations of TC' and LDL- C decreased hy 28.9% and 31.5% in the cerivastatin group(P <0.001) and by 28.0% and 33.0% in control group(P<0. 001) respectively. (2) Cerivastatin significantly decreased serum triglyccride(TG) levcls(F<0. 05) .(3) The lipoprotein a levels decreased by 35.3% (P<0.01) and 27.8% (P<0.05) in the cerivastatin and simvastatin groups after 4 weeks of treatment, respectively. CONCLUSION: Cerivastatin could markedly decrease TC and LDL - C concentrations in patients with hyperlipidemia and the effects of cerivastatin were the same as those of simvastatin, however, lowering effect of cerivastatin on TG was superior to that of simvastatin.
出处
《中国医院用药评价与分析》
2001年第1期39-40,共2页
Evaluation and Analysis of Drug-use in Hospitals of China
