摘要
目的 了解 2型糖尿病并糖尿病肾病患者外周血超氧化物岐化酶水平及用胰岛素治疗后超氧化物岐化酶的变化。方法 A组为 4 6例 2型糖尿病并糖尿病肾病 ,B组为 4 3例血糖控制稳定的 2型糖尿病 ,C组为对照组 4 0例 ,分组对照比较。用黄嘌呤酶法检测外周血超氧化物岐化酶。结果 A、B、C三组样本SOD值比较 ,A组的总SOD、CuZn -SOD、Mn -SOD明显低于B组和C组 (P <0 0 1) ,B组和C组间的总SOD、CuZn -SOD、Mn-SOD值差异不显著 (P >0 0 5 )。治疗一疗程后A组病例的总SOD、CuZn -SOD、Mn -SOD值显著升高 (P <0 0 1) ,B组病例总SOD、CuZn -SOD、Mn -SOD值变化不明显 (P >0 0 5 )。同时A组病例的 2 4h尿蛋白量由 (2 736± 6 5 8)mg下降至 (180 5± 5 76 )mg(P <0 0 1)。结论 DN患者体内氧自由基产生增加 ,SOD值降低。胰岛素具有升高SOD和降低尿蛋白的作用。
Objective To investigate superoxide dismutase(SOD) activity in peripheric blood of type 2 diabetic patients(NIDDM) complicated with diabetic nephropathy(DN) and SOD alteration after insulin treatment.Methods Three groups of individuals were selected.Group A included 46 cases of NIDDM patients with DN.Group B included 43 cases of NIDDM patients with stable blood sugar.Group C included 40 cases of normal individual.Xanthine enzyme method was used to test SOD.Results The total SOD(T-SOD),CuZn-SOD,Mn-SOD in group A,B and C were 94 7±10 7,58 3±6 2 and 36 4±4 3;101 6±9 3,61 5±5 6 and 39 6±3 7;104 4±8 9,63 7±5 3 and 40 7±4 1;respectively.The SODs level in group A were significant lower than those in group B and group C(P<0 01).After a course of treatment(three weeks) the T-SOD,CuZn-SOD and Mn-SOD in group A from 67 7±10 7,58 3±6 2 and 36 4±4 3(NU/L) reached to 102 6±11 8,60 8±7 3 and 41 8±5 7(NU/L)(P<0 01).Simultaneous with showed that the 24h excretory urine protein in group A was reduced from (2736±658)mg to (1805±576)mg(P<0 01).Conclusion Free radical injury may be play an important in the developing process of DN with NIDDM.Insulin treatment is valuable to increase SOD and reduce urinary protein in DN patients with NIDDM.
出处
《中国医师杂志》
CAS
2002年第12期1351-1352,共2页
Journal of Chinese Physician
