摘要
目的 :研究胃康宁片中盐酸小檗碱的含量的测定方法。方法 :用紫外分光光度法测定含量 ,以 375nm为测定波长 ,0 .0 5mol·L-1硫酸作对照液。结果 :盐酸小檗碱在 4～ 2 8mg·L-1之间呈良好线性关系。相关系数r =0 .9999,平均回收率为99 .5 5 % (n =5 ) ,RSD为 0 .36 %。结论 :本方法简便 ,准确 ,回收率和重现性均较好 ,适用于生产过程中的快速分析。
OBJECTIVE To develop an assay method for the determination of berberine hydrochlonide in wei kangning tablets.METHODS UV spectrophotometry was selected to determine the content and the 0.05 mol·L -1 sulfuric acid was used as the reference solution. The absorbance was measured at 375 nm.RESULTS The calibration curve for berberiny hydrochloride was linear within the range of 4～28 mg·L -1 ( r = 0.9999 ),The average recovery was 99.55% ( n =5),and the RSD was 0.36% .CONCLUSIONS The method was proved to be simple, precise and reproducible. It is especia11y practicable for the-process analysis.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2003年第10期603-604,共2页
Chinese Journal of Hospital Pharmacy
关键词
胃康宁片
盐酸小檗碱
紫外分光光度法
含量
weikangning tablet
berberine hydrochloride
UV spectrophotomotry
deternination
