摘要
在乌拉坦麻醉的大鼠,研究了去甲肾上腺素(NE)在缰核(Hb)引起的心血管效应及其机制。Hb内微量注射NE使平均动脉压和心率呈剂量依赖性增加。用α受体阻断剂酚妥拉明预处理Hb,可明显减弱NE在Hb引起的心血管效应,但β受体阻断剂心得安或生理盐水不引起任何影响。Hb内微量注射海人酸使平均动脉压和心率明显增加,但Hb内微量注射利多卡因则不能引起明显的心血管效应。上述结果表明,Hb内NE在调节心血管活动中起重要作用,而这种效应可能是通过激活α受体使Hb兴奋的结果。
Cardiovascular effect of norepinephrine (NE) in the habenular nucleus (Hb)and the underlying mechanism were investigated in urethane-anesthetized rats.NE microinjection into Hb produced a dose-dependent increase in mean arterialblood pressure and heart rate, an effect that could be attenuated by the pretreatmentin Hb with α-receptor blocker phentolamine, but not by the pretreatment withβ-receptor blocker propranolol or physiological saline. Microinjection of kainicacid into Hb gave rise to a marked increase in mean arterial blood pressure andheart rate, but microinjection of lidocaine did not elicit significant cardiovasculareffect. The above results suggest that NE in Hb plays an important role in car-diovascular control as a result of Hb excitation through activation of α-receptor.
出处
《生理学报》
CAS
CSCD
北大核心
1992年第2期115-120,共6页
Acta Physiologica Sinica
基金
国家自然科学基金
关键词
心血管效应
去甲肾上腺素
缰核
habenular uncleus
norepinephrine
phentolamine
propranolol
kainic acid, lidocaine
blood pressure
heart rate
