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脊髓中的环氧化酶及其与疼痛的关系 被引量:4

Cyclooxygenases in the spinal cord and the relationship with pain
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摘要 脊髓中的环氧化酶 (COX)有COX 1和COX 2两种同工酶 ,其在脊髓中的细胞和亚细胞定位、与痛和痛过敏的关系等均有不同。选择性抑制COX 2的非甾体抗炎药副作用较小 ,对抗炎。
出处 《生理科学进展》 CAS CSCD 北大核心 2003年第4期359-360,共2页 Progress in Physiological Sciences
基金 河北省科技攻关项目资助课题 (982 76 196D)
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参考文献10

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  • 2Yamamoto T, Nozaki-Taguchi N. The role of cyclooxygenase-1 and -2 in the rat formalin test. Anesth Analg, 2002,94:962 - 967.
  • 3Beiche F, Brune K, Geisslinger G, et al. Expression of cyclooxygenase isoforms in the rat spinal cord and their regulation during adjuvant-induced arthritis. Inflamm Res, 1998,47:482 - 487.
  • 4Chandrasekharan NV, Dai H, Roos KL, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci USA, 2002, 99 : 13926 -13931.
  • 5Schwab JM, Brechtel K, Nguyen TD, et al. Persistent accumulation of cyclooxygenase-1 ( COX-1 ) expressing microglia/macrophages and upregulation by endothelium following spinal cord injury. J Neuroimmunol, 2000, 111 : 122 -130.
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  • 8Sinatra R. Role of COX-2 inhibitors in the evolution of acutepain management. J Pain Symptom Manage, 2002, 24 : S18- 27.
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