摘要
研究目的 探讨小儿反复呼吸道感染与外周血T细胞亚群变化的关系。 研究设计 病例对照研究。 患者和其他参与者 反复呼吸道感染患儿32例,男21例,女11例。对照组为20例健康儿童,男13例,女7例。 处理方法 所有患者和参与者均于上午8时采血送检。 检测和主要结果 用OKT单克隆抗体检测了32例患儿和20例健康儿童外周血T细胞亚群。结果显示:复感儿组与对照组OKT_3的百分率分别为56.21±7.19和61.42±4.87(P<0.01),OKT_4分别为37.27±3.45和39.35±3.52(P<0.05),OKT_8分别为30.69±3.94和28.14±4.22(P<0.05),OKT_4/OKT_3分别为1.31±0.14和1.41±0.16(P<0.05)。 结论 反复呼吸道感染患儿外用血 OKT_3、OKT_4降低,OKT_3升高,OKT_4/OKT_3降低。提示该病患儿不仅细胞免疫功能低下,而且T细胞亚群比例失调。
Objective To search for the relationship between recurrent respiratory Infection(RRI)and the changesof T cell subpopulation of peripheral blood in child patients. Design Case-control research Patients and Other Participants Thirty-two cases of RRI, 21 male and 11 female. There are 20 health children in control group, 13 male and 7 female. Interventions The blood of all the patients and participants were drawn and delivered for measurementat 8 o' clock in the morning. Measurements and Main Results The peripheral blood T cell subpopulation of 32 cases and 20 healthchildren had been determined by OKT monoclonal antibody. The results show that OKT_3 percentages ofRRI group and control group are 56.21±7.19 and 61.42±4.87 (P<0.01), OKT_4 are 37.27±3.45 and39.35±3.52 (P<0.05). OKT_8 are 30.69±3.94 aud 28.14±4.22 (P<0.05) respectively. The values ofOKT_4 /OKT_8 of the two group are 1.31±0.14 and 1.41±0.16 (P<0.05) respectively. Conclusions The peripheral blood OKT_3 and OKT_4 are decreased, OKT_8 are incrcased in the childpatients with RRI, OKT_4 /OKT_8 is decreased. It is suggested that the cellular immune function wouldbe decreased and the proportion of T cell Subpopulation would be imbalance in child patients with RRI.
出处
《实用儿科临床杂志》
CAS
CSCD
1992年第4期176-178,共3页
Journal of Applied Clinical Pediatrics
关键词
呼吸道感染
T细胞亚群
免疫调节
recurrent respiratory infection
T cell subpopulation
immunoregulation
