摘要
目的:探讨贲门区幽门螺杆菌(HP)感染与贲门癌发生、发展之间的关系.方法:对126例正常人和良性胃十二脂肠疾病患者的贲门区、胃体小弯和胃窦部的粘膜活检组织和17例贲门癌患者的癌灶、癌旁、胃体小弯和胃窦部的活检组织进行快速尿素酶试验,并用PCR的方法对贲门癌标本中多种Hp基因进行扩增.结果:①慢性活动性胃炎、十二指肠球部溃疡、贲门癌患者胃内Hp的感染率比正常人明显增高(P<0.01);②贲门癌灶及癌旁组织内Hp的感染率较对照组明显增高,分别为70.6%和88.2%;③癌灶Hp-PCR阳性率为75.8%.结论Hp的持续感染与慢性活动胃炎、十二指肠球部溃疡和贲门癌有关.
Objective: Little attention has been paid to the prevalence of helicobacter pylori (Hp) in cardia. The aim of this study was to determine if Hp was associated with cardiac cancer. Method: 143 consecutive esophagogastroduodenoscopy patients were recruited , 17 with cardiac cancer and 126 macroscopically normal but with benign gastroduodeno-disorder. Multiple biopsies were taken from paracardiac tumour, centre of tumour, curvatura ventriculi minor and antrun for histology and rapid ureas tests. Multiple genes of Hp of the resections of cardiac cancer were detected by PCR . Results:(1) the Hp infecton rates of chronic activity gastritis, duodeno ulcer and cardiac cancer were much higher than those of the normal's (P<0.01) ;(2)the Hp infection rates of cardiac cancer and its paraside were much higher than those of the control's, 70.6% vs. 88.2% ;(3)the expression of Hp- PCR of cardiac cancer was 80.0% .Conclusion: It is suggested the continuous Hp infection may contribute to the occurence of chronic activity gastritis, duodeno ulcer and cardiac cancer.
出处
《临床肿瘤学杂志》
CAS
1999年第4期30-32,共3页
Chinese Clinical Oncology
