摘要
目的 :探讨中药强骨膏对去卵巢形成的骨质疏松大鼠骨密度、生物力学及性激素的影响。方法 :通过切除大鼠卵巢形成骨质疏松模型 ,观察强骨膏对骨质疏松大鼠骨密度、股骨最大载荷等生物力学指标和血清雌二醇的影响 ,并与葡萄糖酸钙及龙牡壮骨冲剂对照。结果 :强骨膏治疗的去卵巢骨质疏松大鼠的骨密度值 ,最大载荷、最大应力、屈服点值及雌二醇均明显高于模型组。结论 :强骨膏能提高去卵巢骨质疏松大鼠的骨密度 ,增强抗外力冲击的能力 ,其作用机理可能与其拟雌激素样作用有关。
Objective: To observe the effects of Qianggu electuary(QGE),a Chinese herbal preparation, on ovariectomy-induced osteoporotic rats. Method: Female Wistar rats were ovariectomized and administered QGE,calcium gluconate(CG) and Longmu Zhuanggu granules(LMZG) for 12 weeks. Bone mineral density(BMD),indexes of biomechanics and serum E 2,Ca were detected in grouped rats including QGE,CG,LMZG and control groups. Result: QGE could significantly increase the BMD and maximum load, maximum stress YP-load of femora in the osteoporotic rats. The values of E 2 in ovariectomized osteoporotic rats decreased, compared with those of control normal rats( P >0.05),while in the QGE treated rats, the values of E 2 increased. Conclusion: QGE can incrcease the BMD and improve indexes of bone biomechanics in ovariectomized osteopotic rats ,possibly due to its estrogen-like effect.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2003年第10期970-973,共4页
China Journal of Chinese Materia Medica
关键词
强骨膏
去卵巢大鼠
骨质疏松
实验研究
中药
Qianggu electuary
osteoporosis
ovariectomized rats
bone mineral density
biomechanics
estrogen
