摘要
目的 探讨血瘀证量化诊断的方法和血瘀证证候实质。方法 对临床预试验血瘀证症状体征及客观指标进行t检验和回归分析。结果 ( 1) 182例血瘀证与非血瘀证患者内皮素、一氧化氮、纤溶酶原激活物 t检验均有显著性差异。 ( 2 ) 170例血瘀证与非血瘀证患者血红蛋白、甘油三酯、总胆固醇、内皮素、一氧化氮、纤溶酶原激活物 6因素的逐步回归显示其贡献度的顺序为内皮素 >血红蛋白 >纤溶酶原激活物 >一氧化氮 ,甘油三酯及总胆固醇未能入选。 ( 3)对 6 0 1例患者血瘀证症状体征 4 0因素逐步回归分析 ,当F =6时选出的 18因素对血瘀证诊断贡献度最大 ,并得一回归方程。将数量化资料代入回归方程进行检验 ,总符合率为 94 .2 4 %。结论 通过多中心、前瞻性、大规模、随机对照的临床流行病学调查和临床试验 ,可以得出病证结合规范且量化的由症状、体征和客观指标构成的标准化中医证候。
Objective To explore the way of quantified diagnosis of blood stasis syndrome (BSS) and the essence of BSS. Methods Using t test and logistic regression to analyze the symptoms, signs, and objective indexes of BSS in clinical test. Results (1) The levels of endothelin, nitric oxide, and t PA between 182 patients with BSS and non BSS had notable difference. (2) The stepwise regression analysis about hemoglobin, triglyceride, total cholesterol, endothelin, nitric oxide, and t PA in 170 patients with BSS or non BSS revealed that the order of these indexes considering their importance was: endothelin, hemoglobin, t PA, nitric oxide. However, the triglyceride and total cholesterol could not enter the regression equations. (3) The stepwise regression analysis about 40 symptoms and signs in 601 patients with BSS or non BSS revealed that the 18 items had the very contribution to diagnose the BSS when the F value was 6, and so a regression equation was available. The total coincidence ratio was 94.24% when the other quantified data about BSS were tested in the equation. Conclusion The standardized TCM syndrome, which accorded with the criteria of combining diseases with syndrome,was made up of symptoms, signs, and objective indexes.The standard could be obtained by multi center, prospective, random and controlled clinical epidemiological survey and clinical test.
出处
《中西医结合学报》
CAS
2003年第1期21-24,共4页
Journal of Chinese Integrative Medicine
基金
国家中医药管理局创新工程资助项目 (CX 0 0 0 2 )
关键词
血瘀证
诊断
中医
回归方程
blood stasis syndrome
quantified diagnosis
multivariate regression
