摘要
目的:探讨常规分割放射治疗联合大剂量烟酰胺治疗鼻咽癌的可行性,观察主要毒性反应和初步疗效。方法:从1999年9月至2000年8月共有20例患者入组研究,采用常规分割放射治疗,同时在鼻咽原发灶每次放疗前30-60分钟口服烟酰胺片,单次剂量为50mg/kg。结果:20例患者有18例完成预定的治疗方案,完成率为90％。主要治疗毒性为:Ⅲ级口腔粘膜急性反应发生率为40％(8/20);Ⅲ级照射野区皮肤急性反应发生率为20％(4/20);Ⅲ级消化道急性反应发生率为20％(4/20),主要表现为恶心和呕吐。所有患者中无一例出现Ⅳ级毒副反应。2例出现轻度的骨髓抑制。治疗后无明显的肝脏、肾脏和心脏毒性。治疗后鼻咽病灶的有效率(CR+PR)为100％,其中CR率为85％(17/20);2年鼻咽原发灶控制率、无远处转移率和生存率分别为94.7％、95％和95％。结论:用常规分割放射治疗联合大剂量烟酰胺治疗鼻咽癌的方案可行,近期疗效较满意。
Objective:The feasibility, toxicity and clinical effectiveness was assessed in patients with nasopharyngeal carcinoma treated by conventional radiotherapy with nicotinamide. Methods: From September 1999 to August 2000, twenty patients with nasopharyngeal carcinoma were treated by conventional radiotherapy with nicotinamide. All patients orally received 50 mg/kg/fraction of the drug. Results:In all patients, two failed to complete treatment. The most common side-effects were nausea and vomiting, oral mucosa and skin acute reaction, their appearance of III grade reaction were 4(20% ) , 8(40% ) and 4(20% ) patients, respectively. Two patients had mild marrow suppression and no patients had liver, kidney and heart toxicity. Primary tumor was complete response in 17 patients. The local control rate, free from distant metastasis rate and actuarial survival rate at 2-year were 94. 7% ,95% and 95%. Conclusion: Conventional radiotherapy with nicotinamide is feasible in patients with nasopharyngael carcinoma. The preliminary clinical effectiveness is satisfied.
出处
《临床肿瘤学杂志》
CAS
2003年第6期442-444,共3页
Chinese Clinical Oncology
基金
上海市卫生局专项基金(9741O)资助
