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Prognostic factors in 165 elderly colorectal cancer patients 被引量:8

Prognostic factors in 165 elderly colorectal cancer patients
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摘要 AIM: To analyse the prognostic factors in 165 colorectal patients aged ≥70.METHODS: One hundred and sixty-five elderly patients with colorectal cancer diagnosed by histology were entered into the retrospective study between 1994 and 2001. Patients were given optimal operation alone, chemotherapy after operation, or chemotherapy alone according to tumor stage,histology, physical strength, and co-morbid problems.Survival rate was calculated by Kaplan-Meier method, and compared with meaningful variances by Log-rank method.Prognostic factors were analyzed by Cox regression.RESULTS: The 1,2,3,4,5 year survival rate (all-cause rnortality)was 87.76%, 65.96%, 52.05%, 42.77%, 40.51%,respectively. The mean survival time was 41.89±2.33 months (95% CI: 37.33-46.45 months), and the median survival time was 37 months. Univariate analysis showed that factors such as age, nodal metastasis, treatment method, Duke's stage, gross findings, kind of histology, and degree of differentiation had influences on the survival rate. Multivariate analysis showed that factors such as treatment method,Duke's stage, kind of histology and degree of differentiation were independent prognostic factors.CONCLUSION: This study suggests that the prognosis of elderly colorectal cancer patients is influenced by several factors. Most of elderly patients can endure surgery and/or chemotherapy, and have a long-time survival and good quality of life. AIM:To analyse the prognostic factors in 165 colorecta patients aged≥70. METHODS:One hundred and sixty-five elderly patients with colorectal cancer diagnosed by histology were entered into the retrospective study between 1994 and 2001.Patients were given optimal operation alone,chemotherapy after operation,or chemotherapy alone according to tumor stage, histology,physical strength,and co-morbid problems. Survival rate was calculated by Kaplan-Meier method,and compared with meaningful variances by Log-rank method. Prognostic factors were analyzed by Cox regression. RESULTS:The 1,2,3,4,5 year survival rate(all-cause mortality) was 87.76 %,65.96 %,52.05 %,42.77 %,40.51%, respectively.The mean survival time was 41.89±2.33 months (95 % CI:37.33-46.45 months),and the median survival time was 37 months.Univariate analysis showed that factors such as age,nodal metastasis,treatment method,Duke's stage,gross findings,kind of histology,and degree of differentiation had influences on the survival rate.Multivariate analysis showed that factors such as treatment method, Duke's stage,kind of histology and degree of differentiation were independent prognostic factors. CONCLUSION:This study suggests that the prognosis of elderly colorectal cancer patients is influenced by several factors.Most of elderly patients can endure surgery and/or chemotherapy,and have a long-time survival and good quality of life.
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 2003年第10期2207-2210,共4页 世界胃肠病学杂志(英文版)
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  • 1Yong Chuan Deng1,Yong Su Zhen2,Shu Zheng1,Yu Chuan Xue2 1Cancer Institute, Medical School, Zhejiang University, Hangzhou 310009, Zhejiang Province, China2Institute of Medicinal Biotechnology, CAMS & PUMC, Beijing 100050, China.Activity of boanmycin against colorectal cancer[J].World Journal of Gastroenterology,2001,7(1):93-97. 被引量:5
  • 2Ping Yuan~1 Meng Hong Sun~2 Jin Sheng Zhang~1 Xiong Zeng Zhu~2 Da Ren Shi~2 ~1Department of Pathology,Medical College of Fudan University,~2Department of Pathology,Cancer Hospital/Cancer Institute,Fudan University,Shanghai 200032,ChinaDr.Ping Yuan Studying Province.studying in Medical College of Fudan University,worked in Department of Pathology,Wannan Medical College,having eighteen papers published..APC and K-ras gene mutation in aberrant crypt foci of human colon[J].World Journal of Gastroenterology,2001,7(3):352-356. 被引量:20
  • 3Jun Hui Cui~1 Uwe Krueger~2 Doris Henne-Bruns~2 Bemd Kremer~2 Holger Kalthoff~2 ~1Department of General Surgery,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,Zhejiang Province,China ~2Department of General Surgery,Christian-Albrechts-University,Kiel,GermanyDr.Jun Hui Cui graduated from Zhejiang Medical University in 1984,earned master degree in 1990,studied in the Surgical Department of Kiel University and worked in the Lab of Molecular Oncology of Kiel University from 1994-1997achieved M.D.from Kiel University.Germany,now associate professor of surgery,specialized in colorectal oncology.Adviser of graduated student for master degree,having 20 publications published in key Chinese or English journals..Orthotopic transplantation model of human gastrointestinal cancer and detection of micrometastases[J].World Journal of Gastroenterology,2001,7(3):381-386. 被引量:19
  • 4Xiao Wei Li~1 Yan Qing Ding~1 Jun Jie Cai~1 Shao Qing Yang~2 Lian Bing An~3 Dong Fang Qiao~3 ~1Department of Pathology,Nanfang Hospital of the First Military Medical University,Guangzhou 510515,Guangdong Province,China ~2The Northern Hospital of PLA,Shenyang 110015,Liaoning Province,China ~3Department of Electronmicroscopy,First Military Medical University,Guangzhou 510515,Gangdong Province,ChinaDr.Xiao Wei Li graduated from the First Military Medical University with a MM degree in 1999.Physician in Charge of pathology,having 6 papers published..Studies on mechanism of Sialy Lewis-X antigen in liver metastases of human colorectal carcinoma[J].World Journal of Gastroenterology,2001,7(3):425-430. 被引量:19
  • 5Chao Xu Zheng~1 Wen Hua Zhan~1 Ji Zong Zhao~2 Dong Zheng~3 Dong Ping Wang~1 Yu Long He~1 Zhang Qing Zheng~1 ~1Department of General Surgery,~2Laboratory of Surgery,~3Department of Medicine,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,Guangzhou 510080,Guangdong Province,ChinaDr.Chao Xu Zheng now working as a surgeon and lecturer in the Department of General Surgery,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,who is a Ph.D.student,having 7 papers published..The prognostic value of preoperative serum levels of CEA,CA19-9 and CA72-4 in patients with colorectal cancer[J].World Journal of Gastroenterology,2001,7(3):431-434. 被引量:25
  • 6Li Ping Wang~1 Ke Liang~2 Yu Shen~2 Wei Bo Yin~2 G.Hans~3 Yan Jun Zeng~1 ~1Biomechanics & Medical Information Institute,Beijing Polytechnic University,Beijng 100022,China ~2Department of Gastrointestinal Surgery,Aalborg University,Denmark ~3Cancer Institute (Hospital),Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100021,ChinaLi Ping Wang graduated from Beijing Polytechnic University in 2000,major in tumor radiotherapy,having 3 papers published..Neutron-induced apoptosis of HR8348 cells in vitro[J].World Journal of Gastroenterology,2001,7(3):435-439. 被引量:5
  • 7Xing-Guo Li Jin-Dan Song Yun-Qing Wang Key Laboratory of Cell Biology,Ministry of Public Health of China,China Medical University,Shenyang 110001,Liaoning Province,China.Differential expression of a novel colorectal cancer differentiation-related gene in colorectal cancer[J].World Journal of Gastroenterology,2001,7(4):551-554. 被引量:7
  • 8GregoryBMakin,DavidJBreen,JohnRTMonson.The impact of new technology on surgery for colorectal cancer[J].World Journal of Gastroenterology,2001,7(5):612-621. 被引量:21
  • 9Jing Yi~1 Zhi-Wei Wang~1 Hui Cang~1 Yu-Ying Chen~1 Ren Zhao~2 Bao-Ming Yu~2 Xue-Ming Tang~1 1 Department of Cell Biology,2 Department of Surgery,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China.p16 gene methylation in colorectal cancers associated with Duke's staging[J].World Journal of Gastroenterology,2001,7(5):722-725. 被引量:21
  • 10Min-Jie Luo Mao-De Lai Department of Pathology,School of Medicine,Zhejiang University,Hangzhou 310031,P.R.China.Identification of differentially expressed genes in normal mucosa,adenoma and adenocarcinoma of colon by SSH[J].World Journal of Gastroenterology,2001,7(5):726-731. 被引量:22

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