摘要
目的:总结隐睾继发精原细胞瘤的临床特点,提高诊治水平。方法:回顾性分析2000年1月~2014年6月中国人民解放军总医院收治的10例隐睾继发精原细胞瘤患者的临床资料及预后信息。结果:10例患者平均年龄38岁,术前均检查甲胎蛋白、人绒毛膜促性腺激素β亚单位等血清学肿瘤指标,并均行腹部B超检查,8例行腹部CT检查,1例行PETCT检查,3例行穿刺活检。9例以腹部包块就诊,肿瘤位于腹腔9例,位于腹股沟1例。本组患者均行手术治疗,临床分期:Ⅰa期1例,Ⅱb期5例,Ⅱc期2例,Ⅲa期1例,Ⅲc期1例,9例术后病理为单纯精原细胞瘤,1例病理为合并有卵黄囊成分精原细胞瘤。术后随访1.5~15.0年,2例失访,7例患者每年定期复查未出现复发及转移,1例术后1年半复发,行6周期化疗及18次放疗后复查肿瘤消失。结论:隐睾患者发生精原细胞瘤的危险性较正常人增加,继发精原细胞瘤患者经过积极的手术治疗配合放疗和化疗,可以获得较好的疗效。
Objective:To improve the diagnosis and treatment of seminoma arising from cryptorchidism by summarizing the clinical features of this disease.Methods:Clinical data and prognostic information of 10 patients with seminoma arising from cryptorchidism admitted to Chinese PLA General Hospital from January 2000 to June2014were retrospectively analyzed.Results:Of the 10 patients,the average age was 38 years,the serological tumor markers alpha-fetoprotein(AFP)and human chorionic gonadotropin in beta subunit(β-HCG)were examined on all cases,and all of those patients were subjected to abdominal B ultrasound,8to abdominal CT,1to PET-CT,and 3to puncture biopsy before operation.Nine cases were initially diagnosed as having abdominal mass.The tumor was located in the abdomen in 9cases,and in the inguinal fold in one case.All cases were given surgery successfully,including 1case of clinical stageⅠa,5cases ofⅡb,2cases ofⅡc,1case ofⅢa and 1case ofⅢc.Post-operative pathologically,there were 9cases of pure seminoma,and 1case of seminoma complicated with yolksac tumor.The 10 patients were followed up for 1.5years to 15 years.Two patients were Lost followup,7patients had no recurrence and metastasis.In one case of recurrence 1.5years after surgery,the recurrent tumor foci disappeared after 6cycles of chemotherapy and 18 times of radiotherapy.Conclusions:Cryptorchidism is a risk factor of seminoma.Patients with seminoma arising from cryptorchidism will achieve satisfactory therapeutic effects after an aggressive surgical treatment supplemented with proper chemotherapy and radiotherapy.
出处
《微创泌尿外科杂志》
2016年第3期183-186,共4页
Journal of Minimally Invasive Urology
基金
国家高新技术研究发展计划(863计划)(2012AA02101)
关键词
隐睾
精原细胞瘤
继发
cryptorchidism
seminoma
secondary
