摘要
目的:观察并评价女贞养阴颗粒对美多巴、安坦治疗震颤麻痹的增效与减毒作用。方法:采用随机双盲方法,对因服美多巴、安坦疗效衰减或出现明显毒副反应的震颤麻痹患者30例加服中药女贞养阴颗粒治疗,并与对照组(加服安慰剂)30例作对比观察。结果:治疗组和对照组的总有效率分别为86.7％和56.7％,证候总进步率分别为90.0％和56.7％,减毒总有效率分别为90.0％和43.3％,两组比较差异均有显著性(P<0.05或P<0.01);同时表明,女贞养阴颗粒对美多巴、安坦在消化系统、神经精神系统、心血管系统的不良反应有明显治疗作用。结论:初步认为女贞养阴颗粒对美多巴、安坦治疗震颤麻痹有明显的增效减毒作用。
Objective: To observe and assess the efficacy enhancing and toxicity attenuating effect of Nuzhen Yangyin Granule (NYG) to the anti-parkinsonism (paralysis agitans) therapy with Medopa and Artane. Methods: Adopting the randomized double-blinded method, the effect of adding NYG to 30 patients with Parkinsonism in the treated group, who already received anti-Parkinsonism treatment but showing decreased response to Medopa and Artane and with obvious adverse reaction, was observed and controlled by 30 patients treated by adding placebo. Results: The total effective rate in the treated group and the control group was 86.7 % and 56.7% respectively, the total syndrome improving rate was 90 % and 56. 7 % respectively and the toxicity attenuating rate 90 % and 43.3 % respectively, comparison between the two groups showed significant difference (P<0.05 or P<0.01). NYG also showed markedly effective in reducing the adverse reactions of Medopa and Artane on digestive, neuro-psychiatric and cardiovascular system. Conclusion: NYG has obvious efficacy enhancing and toxicity attenuating effects caused by the anti-Parkinsonism treatment with Medopa and Artane.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2003年第11期811-814,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
湖南省中医药管理局资助项目(No.20328)
关键词
女贞养阴颗粒
美多巴
震颤麻痹
增效减毒作用
临床观察
Nuzhen Yangyin Granule, paralysis agitans, Medopa, efficacy enhancing and toxic attenuating effect
