摘要
目的 :探讨质子泵抑制剂雷贝拉唑试验对胃食管反流病 (GERD)的诊断价值。方法 :根据临床反流症状、食管 2 4hpH监测以及胃镜检查结果 ,将 93例有反流症状的病人 (78例GERD病人和 1 5例非GERD病人 )随机分为试验组 (雷贝拉唑组 ,45例 )和对照组(安慰剂组 ,48例 )。试验组用雷贝拉唑 2 0mg/d ;对照组用维生素B1 口服 ,2 0mg/d。两组均用药 2周 ,记录服药前后病人烧心、反酸、胸骨后灼痛症状积分的改变 ,按症状积分下降值判定诊断 ,与食管 2 4hpH监测以及胃镜检查结果对比分析。结果 :试验组的GERD病人服药后 5d、7d、2周症状积分下降值分别为 5 .4± 3 .7、7.1± 5 .3、9.8± 6.4,下降率分别为 34.7%、46 .3%、62 .6 %。以症状下降 3分为标准 ,雷贝拉唑试验诊断GERD的价值最佳 ,对服药时间分析 ,则以服雷贝拉唑 5d为佳。结论 :雷贝拉唑治疗试验是GERD临床诊断的一种简单。
Purpose: To observe the diagnostic value of rabeprazole test in gastro-esophageal reflux disease. Methods: According to clinical manifestations and results of esophageal 24 hours pH monitoring and gastro-esophageal endoscopy,93 patients with reflux symptoms(78 GERD, 15 non-GERD)were randomly divided into trail group(45 patients)and control group(48 patients). The patients in trail group received rabeprazole 20 mg/d and the patients in control group received vitamin B 1 20 mg/d.Symptom score from heartburn , acid regurgitation,and substernal pain , was recorded before and after taking rabeprazole or vitamin B 6. Results: The symptom score decreasing from GERD of trail group was 5.4±3.7、7.1±5.3、9.8±6.4 after taking rabeprzole 5 days , 1 week , and 2 weeks respectively , score decreasing 3 was the best critical value for GERD diagnosis. The result showed that rabeprazole test has the best diagnostic value with 5 days. Conclusion: Rabeprazole test is reliable for GERD diagnosis.
出处
《临床消化病杂志》
2003年第5期205-207,共3页
Chinese Journal of Clinical Gastroenterology
