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单核苷酸多态性(SNPs)——第三代DNA分子标记 被引量:6

Single nucleotide polymorphisms(SNPs)、third generation of DNA molicular marker
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摘要 单核苷酸多态性 (SNPs)是指染色体基因组水平上由单个核苷酸变异引起的DNA序列多态性 ,具有分布广、密度高、多态性丰富等特点 ,且易于实现自动化检测 ,被公认为是最新的第 3代DNA分子标记。其在基因作用机理、疾病的研究及动物育种等领域具有广泛的应用前景。本文简要介绍了 6种高通量的SNPs检测技术 :基因芯片、TaqMan、变性高效液相色谱、双色荧光偏振检测入侵、基质辅助激光解吸附电离飞行时间质谱及单碱基延伸标签阵列的原理及其优、缺点。
作者 陈艺 吴登俊
出处 《畜牧与兽医》 北大核心 2003年第12期37-39,共3页 Animal Husbandry & Veterinary Medicine
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