摘要
目的 探讨 2型糖尿病微血管和大血管病变与外周血白细胞计数之间的关系。方法 分析了 6 4 1例 2型糖尿病住院患者和 6 5例正常对照组 (D0 )体脂参数、血压、血脂、血糖、外周白细胞计数水平 ,采用稳态模式 (HOMA)评价胰岛素抵抗和胰岛分泌功能。结果 糖尿病微血管病变组 (D2 )、糖尿病大血管病变组 (D3 )和糖尿病同时合并微血管和大血管病变组 (D4)的体重指数 (BMI)、收缩压 (SBP)、舒张压 (DBP)、空腹血糖 (FBG)、甘油三酯 (TG)和稳态模式评价的胰岛素抵抗 (HOMA IR)水平均高于正常对照组 (D0 ) (P <0 .0 1) ,高密度脂蛋白胆固醇 (HDL C)和稳态模式评价 β细胞功能 (HOMA β)低于D0 组 (P <0 .0 1)。D2 、D3 和D4组白细胞计数 (WBC)水平高于D0 组 (P <0 .0 5 )。D2 与D0 组患者Spearman相关分析显示 ,白细胞计数与SBP(r =0 .195 ,P <0 .0 5 ) ,DBP(r =0 .14 6 ,P <0 .0 5 ) ,TG(r =0 .2 0 5 ,P <0 .0 0 1) ,体重指数 (r =0 .15 8,P <0 .0 5 ) ,组别 (r =0 .195 ,P <0 .0 0 1) ,尿蛋白排泄率 (r =0 .2 38,P <0 .0 0 1)呈正相关。D3 与D0 组患者Spearman相关分析显示 ,白细胞计数与SBP(r =0 .2 11,P <0 .0 5 ) ,BMI(r =0 .2 16 ,P <0 .0 5 ) ,TG(r =0 .2 90 ,P <0 .0 0 1) ,HOMA IR(r =0 .2 4 2 ,P
Objective To investigate the relevance of microangi opathy and macroangiopathy in type 2 diabetes to white blood cell count. Methods Anthropometrical parameters, blood pressure(BP), ser um lipids ,serum glucose and white blood cell count(WBC) were analyzed in 641 ty pe 2 diabetes mellitus(T2DM) and 65 control subjects(D 0). Homeostasis model as sessment(HOMA) was applied to assess the status of insulin resistance and excret ion. Results Levels of body mass index(BMI), systolic blood pressure( SBP), diastolic blood pressure(DBP), fasting blood glucose(FBG), serum triglycer ide(TG) and HOMA-IR were significantly elevated,while their high density lipo protein-cholesterol(HDL-C) and HOMA-β were decreased in the patients with di abetic microangiopathy only(D 2), diabetic macroangiopathy only(D 3) and unite d two complication(D 4) compared with control subjects(D 0)(P< 0.01).T he levels of white blood cell count in D 2, D 3 and D 4 groups were significa ntly higher than those of D 0 group(P< 0.05). Spearman correlation ana lysis showed that white blood cell count(WBC) was positively correlated to SBP( r= 0.195,P< 0.05),DBP(r= 0.146,P< 0.05),BMI(r= 0.158,P< 0.05),group(r= 0.195,P< 0.001),TG(r= 0. 205,P< 0.001),UAER(r= 0.238, P< 0.001) in D 2 and D 0 group patients. White blood cell count was positively associated with SBP(r= 0.211,P< 0.05),BMI(r= 0.216,P< 0.05),TG(r= 0.290 ,P< 0.001),HOMA-IR(r= 0.242,P< 0.05),group(r= 0.2 71,P< 0.05) in D 3 and D 0 group patients. Conclusion Chronic subclinical inflammation may play an importan t role in the pathogenesis of microangiopathy and macroangiopathy in type 2 diab etes.
出处
《临床荟萃》
CAS
北大核心
2003年第24期1400-1403,共4页
Clinical Focus
关键词
糖尿病
非胰岛素依赖型
炎症
并发症
白细胞计数
diabetes mellitus, non-insulin-dependent
inflamm ation
complication
leukocyte count
