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IL-17与疾病相关的研究进展 被引量：5

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摘要 IL 17是目前新发现的主要由CD4 + 记忆T淋巴细胞、单核细胞等分泌的一种前炎性细胞因子 ,具有强大的招募中性粒细胞、促进多种细胞释放炎性因子、促进细胞增殖及抑制部分肿瘤生长等多种生物学作用 ,目前研究发现其与机体多种疾病相关 ,特别是肺部感染、哮喘、类风湿性关节炎、器官移植、肠道炎症等炎症性疾病关系密切 ,本文就IL 17在各种疾病中的作用加以综述。
作者 张景熙 李强 刘忠令
机构地区 第二军医大学长海医院呼吸内科医师 第二军医大学长海医院呼吸内科
出处 《国外医学（免疫学分册）》 2004年第1期52-55,共4页 Foreign Medical Sciences(Section of Immunology Foreign Medical Sciences)
关键词 IL-17 中性粒细胞 细胞因子
分类号 R392.11 [医药卫生—免疫学]
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参考文献20

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同被引文献46

  • 1王峰,黄安斌.IL-17在类风湿性关节炎中的作用[J].国际骨科学杂志,2006,27(5):301-303. 被引量：12
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  • 3Richmond JF,Mustafa F,Lu S,et al.Screening of HIV-1 Env glycoproteins for the ability to raise neutralizing antibody using DNA immunization and recombinant vaccinia virus boosting.Virology,1997,230(2):265-274.
  • 4Su B,Wang J,Wang X,et al.The effects of IL-6 and TNF-alpha as molecular adjuvants on immune responses to FMDV and maturation of dendritic cells by DNA vaccination.Vaccine,2008,26 (40):5111-5122.
  • 5Kom T,Bettelli E,Oukka M,et al.IL-17 and Th17 cells.Annu Rey Immunol,.2009,27:485-517.
  • 6Murugaiyan G,Mittal A,Weiner HL.Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4~+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis.J Immunol,2008,181 (11):7480-7488.
  • 7Wong CK,Lit LC,Tam IS,et al.Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematoans:implications for Th17-mediated inflammation in auto-immunity.Clin Immunol,2008,127(3):385-393.
  • 8Kehlen A,Thiele K,Riemann D,et al.Expression,modulation and signalling of IL-17 receptor in fibroblnst-like synoviocytns of patients with rheumatoid arthritis.Clin Exp Immunol,2002,127 (3):539-546.
  • 9Garley M,Jablonska E,Grabowska SZ,et al.IL-17 family cytokines in neutrophils of patients with oral epithelial squamons cell carcinoma.Neoplasm,2009,56(2):96-100.
  • 10Arican O,Aral M,Sasmaz S,et al.Serum levels of TNF-alpha,IFN-gamma,IL-6,IL-8,IL-12,IL-17,and IL-18 in patients with active psoriasis and correlation with disease severity.Mediators Inflamm,2005,5:273-279.

引证文献5

二级引证文献11

国外医学（免疫学分册）
2004年 第1期

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