摘要
肝衰竭是临床常见的严重肝病症候群,病死率极高,除肝移植外,目前尚无有效的治疗方法。人工肝支持系统是治疗肝功能衰竭的重要方法之一,主要包括非生物型人工肝和生物型人工肝。结合了功能性肝细胞的生物型人工肝装置可发挥肝脏解毒、合成、代谢等功能,并且可以部分替代人体肝脏功能。生物型人工肝研发的关键在于种子细胞的筛选和生物反应器的构建。具有良好特性种子细胞的生物人工肝对于肝衰竭的疗效已在一些临床前研究中得以体现,并且目前已启动了多个生物人工肝的临床研究。该文从种子细胞的来源、生物反应器结构分类和临床应用等不同方面,对目前生物型人工肝的发展现状进行了综述。
Liver failure is a complex and progressive syndrome with high mortality.Liver transplantation is the final option.Artificial liver support devices are one of the solutions to treat liver failure,which include nonbiological artificial liver devices and bioartificial liver devices.Bioartificial liver devices containing functional hepatocytes provide the supportive functions close to liver,including detoxification,synthetic functions and biotransformation activities.High-quality hepatocytes and optimized bioreactors are critical to develop an effective bioartificial liver device.The efficacy of bioartificial liver with good functional cells has been confirmed in preclinical studies,while clinical trials are conducted by different groups.This paper reviewed the status in quo of bioartificial liver devices by focusing on the source of functional cells,the types of bioreactor,and the ongoing clinical researches.
作者
武之涛
彭青
高毅
潘国宇
Wu Zhitao;Peng Qing;Gao Yi;Pan Guoyu(Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai200120,China;Zhujiang Hospital,Southern Medical University,Guangzhou510282,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2019年第4期594-600,共7页
Chinese Journal of Cell Biology
关键词
肝衰竭
人工肝
生物人工肝
肝细胞
生物反应器
liver failure
artificial liver
bioartificial liver
hepatocyte
bioreactor
