摘要
自噬和凋亡是哺乳动物清除体内自身物质的两种重要生理过程,不同之处在于前者利于细胞生存,后者促进细胞死亡,它们在组织稳态、发育和疾病中起主要作用。Bcl-2蛋白家族对自噬和凋亡的信号通路存在交叉调控,使细胞的生死抉择具有可控性的同时形成复杂的信号转导网络,导致人们对其机制不甚清楚。该文首先总结了Bcl-2蛋白家族通过调节线粒体外膜通透和钙信号进而调控凋亡的分子机制,然后讨论了该家族成员的相互作用及其对钙信号的影响在自噬信号通路中的关键作用,最后提出了Bcl-2蛋白家族通过调节凋亡和自噬决定细胞命运的观点。
Autophagy and apoptosis are two prominent processes of self-renewal in mammals.Autophagy often prolongs cell survival,while apoptosis promotes cell death.They play a vital role in tissue homeostasis,development and diseases.Autophagy and apoptosis have intersecting signaling pathways mediated by Bcl-2 protein family,which can control the cell fate and form a complex signal transduction network.Thus,the precise mechanisms of Bcl-2 protein family in regulating autophagy and apoptosis still remain elusive.In this review,we first summarized the molecular mechanisms that Bcl-2 family proteins control apoptosis by modulating not only mitochondrial outer membrane permeabilization but also mitochondrial calcium signal.We discussed the pivotal role of the interaction among Bcl-2 family proteins and their involvement in calcium signal in autophagic pathways.Finally,we proposed that Bcl-2 protein family can govern the cell fate by fine-tuning the balance between apoptosis and autophagy.
作者
许国平
杨鹏
祁宏
Xu Guoping;Yang Peng;Qi Hong(Complex Systems Research Center,Shanxi University,Taiyuan030006,China;Shanxi Key Laboratory of Mathematical Techniquesand Big Data Analysis on Disease Control and Prevention,Taiyuan030006,China;Institute of Biotechnology,Shanxi University,Taiyuan030006,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2019年第6期1127-1134,共8页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:11504214、31800657)资助的课题~~
