摘要
目的:探讨γ-干扰素、万托林联合甲泼尼龙琥珀酸钠辅助治疗小儿毛细支气管炎(简称毛支)的疗效及安全性。方法:收治毛支患儿150例,随机分为对照组、治疗A组和治疗B组。3组均给予常规治疗,治疗A组加用γ-干扰素及万托林雾化吸入,B组在A组基础上加甲泼尼龙琥珀酸钠静滴。观察3组疗效、临床症状、体征消失时间、平均住院日及不良反应。结果:治疗B组有效率高于对照组(P<0.01);咳嗽、喘憋、哮鸣音、湿啰音消失时间及平均住院日短于A组(P<0.01)及对照组(P<0.01);咳嗽消失时间与A组比较差异无统计学意义(P>0.05)。结论:γ-干扰素、万托林雾化吸入联合甲泼尼龙琥珀酸钠辅助治疗小儿毛支能提高治疗有效率,缩短病程及住院时间,使用安全。
Objective:To investigate the efficacy and safety of interferon,ventolin combined with methylprednisolone in the treatment of children with bronchiolitis.Methods:150 children with bronchiolitis were selected,they were randomly divided into the control group,the treatment A group,and the treatment B group.3 groups were given conventional treatment,the treatment A group plus γ-interferon and ventolin aerosol inhalation,the treatment B group plus methylprednisolone static drip on the basis of A group.We observed the curative effect,clinical symptoms,signs disappeared time,average hospitalization days and adverse reaction of 3 groups.Results:The effective rate of treatment B group was higher than that of the control group(P<0.01);cough,wheezing,wheezing sound,wet rales disappearance time and average hospitalization days of B group were shorter than that of A group(P<0.01)and the control group(P<0.01);we compared the cough disappeared time of B group with that of the A group had no significant difference(P>0.05).Conclusion:γ-interferon、ventolin aerosol inhalation combined with methylprednisolone in the treatment of children with bronchiolitis can improve the treatment efficiency,shorten the course of disease and hospitalization time,the use is safety.
