摘要
目的:探讨硝普钠与多巴胺和呋塞米合用治疗顽固性心衰的疗效。方法:收治顽固性心力衰竭患者86例,分为观察组与对照组,对照组使用利尿药、血管紧张素转换酶抑制剂、洋地黄强心类药进行治疗;治疗组在对照组治疗方案的基础上,再使用10~20mg多巴胺、25mg硝普钠、35ml 0.9%的氯化钠注射液通过静脉泵入,以2ml/小时的频率进行,5~7天1个疗程,对两组的治疗效果进行对比与分析。结果:治疗组的治疗有效率明显高于对照组,存在较大差异,有统计学意义(P<0.05),且两组均未出现不良反应,例如电解质紊乱、洋地黄中毒等。结论:硝普钠与多巴胺和呋塞米合用治疗顽固性心力衰竭患者,不仅能够扩张患者的血管,有效降低了外周阻力,而且还能够提高患者心肌的收缩力和心输出量,有效减少了血容量,降低患者心脏的前负荷,3种药物在顽固性心力衰竭患者治疗过程中属于相辅相成的关系,有效提高了顽固性心力衰竭患者的治疗效果,具有非常重要的意义。
Objective:To explore the curative effect of sodium nitroprusside combined with dopamine and furosemide in the treatment of refractory heart failure.Methods:86 patients with refractory heart failure were selected,they were divided into the observation group and the control group.The control group was treated with diuretics,angiotensin converting enzyme inhibitors and digitalis drugs.The treatment group added 10~20mg dopamine,25mg sodium nitroprusside and 35ml 0.9%physiological saline by venous pump with the frequency of 2ml/hours.5~7 days were 1 treatment course.The treatment effect of the two groups were compared and analyzed.Results:In the treatment group,the effective rate was significantly higher than the control group,the difference was statistically significant(P<0.05);The two groups were no adverse effects,such as electrolyte disorder,digitalis poisoning and so on.Conclusion:The combination of sodium nitroprusside with dopamine and furosemide in the treatment of refractory heart failure can not only expand the patient's blood vessels and reduce the peripheral resistance,but also can improve the contractility and cardiac output in patients and effectively reduce the blood volume and the load of the heart.The three drugs in the treatment of refractory heart failure are complementary relationship.They effectively enhance the treatment effect of patients with refractory heart failure,and has a very important significance.
关键词
硝普钠
多巴胺
呋塞米
顽固性心衰
疗效观察
Sodium nitroprusside
Dopamine
Furosemide
Refractory heart failure
Curative effect observation
