摘要
目的:探讨急腹症患者早期预防性应用奥美拉唑对术后应激性溃疡(SU)的预防效果。方法:2年间收治急腹症行腹部手术患者320例,随机分为治疗组和对照组。治疗组术后常规予以奥美拉唑注射液40mg/次,2次/日,静滴;对照组手术后予以西咪替丁注射液0.4g/次,2次/日,静滴。观察并记录手术后7天急性SU的发生率。结果:对照组SU的发生率高于治疗组,差异具有统计学意义(χ2=6.81,P<0.01)。治疗组与对照组药物不良反应差异无统计学意义(P>0.05)。结论:急腹症患者术后尽早应用奥美拉唑可以有效预防SU的发生,且不良反应少,较为安全、经济、可靠。
Objective:To investigate the effect of early prophylactic omeprazole in prevention of postoperative stress ulcer. Methods:320 patients with acute abdomen underwent abdominal operation during 2 years were selected,and they were randomly divided into the treatment group and the control group.The treatment group were given conventional omeprazole injection 40mg every time after operation,2/day,intravenous drip.The control group were given cimetidine injection 0.4g every time after operation2/day,intravenous drip.Observed and recorded the incidence of acute stress ulcer for 7 days after operation.Results:The incidence of acute stress ulcer in the control group was higher than in the treatment group,and the difference was statistically significant(χ2=6.81, P<0.01).The incidence of aderse eents between the treatment group and the control group had no significant difference(P>0.05).Conclusion:The application of omeprazole early after acute abdomen operation can prevent the stress ulcer effectively,and it is less adverse reaction, safety and reliable.
