摘要
目的:探讨奥美拉唑、阿莫西林联合克拉霉素与奥美拉唑、左氧氟沙星联合甲硝唑两种三联疗法根除幽门螺杆菌(Hp)阳性消化性溃疡临床疗效差异。方法:2013年5月-2014年5月收治幽门螺杆菌阳性消化性溃疡患者170例,随机分成奥美拉、阿莫西林联合克拉霉素组(A组)和奥美拉唑、左氧氟沙星联合甲硝唑组(B组)各85例,A组:奥美拉唑片20 mg/次,2次/日;阿莫西林胶囊110 g/次,2次/日;克拉霉素0.15 g/次,2次/日;于饭后服用,疗程1周。后继续单独给予奥美拉唑片20 mg/次,2次/日,连续给药7~10天。B组:奥美拉唑片20 mg/次,2次/日;左氧氟沙星0.2 g/次,甲硝唑0.4 g/次,2次/日,饭后服用,疗程1周。结果:A组痊愈42例,显效30例,好转11例,无效2例,总有效率97.6%。B组痊愈41例,显效31例,好转10例,无效3例,总有效率96.5%。两组疗效比较差异无统计学意义(P>0.05),A组根除Hp80例,根除率90.9%,B组根除Hp77例,根除率90.6%,两组比较差异无统计学意义(P>0.05)。结论:两种三联疗法根除幽门螺杆菌阳性消化性溃疡疗效无显著性差异,可根据患者的情况给予治疗。
Objective:To investigate differences of the clinical efficacy of two kinds of triple therapy:omeprazole,amoxicillin combined with clarithromycin and omeprazole,levofloxacin combined with metronidazole in eradication of Helicobacter Pylori Positive Peptic ulcer.Methods:170 cases with Helicobacter pylori positive peptic ulcer were selected from May 2013 to May 2014.They were randomly divided into the omeprazole, amoxicillin combined with clarithromycin group(A group) and omeprazole,levofloxacin combined with metronidazole group(B group) with 85 cases in each.A group:Omeprazole tablets 20 mg/time,2times/day;Amoxicillin Capsules 110 g/time,2times/day;clarithromycin 0.15 g/time,2times/day;after meals,the course of treatment was 1week.Then continue to give omeprazole tablets 20 mg/time,2times/day,administered continuously for 7~10 days.B group:Omeprazole tablets 20 mg/time,2times/day;Levofloxacin 0.2 g/time,metronidazole 0.4 g/time,2 times/day,after meals,for 1 weeks.Results:In A group,42 cases were cured;30 cases were markedly effective;11 cases were improved;2 cases were ineffective;the total efficiency was 97.6%.In B group:41 cases were cured;31 cases were markedly effective;10 cases were improved;3 cases were ineffective;the total efficiency was 96.5%.There was no significant difference in efficacy between two groups(P>0.05).In A group:80 cases of Hp were eradicated,and the eradication rate was 90.9%.In B group:77 cases of HP were eradicated,and the eradication rate was 90.6%.The two groups had no significant difference(P>0.05).Conclusion:The two kinds of triple therapies for eradication of Helicobacter pylori positive peptic ulcer without significant difference.We can treat them according to the condition of the patients.
