期刊文献+

羟考酮注射液在开胸手术超前镇痛中的应用 被引量:5

Application of oxycodone injection in preemptive analgesia in thoracic surgery
下载PDF
导出
摘要 目的:分析羟考酮注射液在开胸手术超前镇痛中的应用效果。方法:2012年6月-2014年5月收治开胸手术患者80例,随机方法分组。对照组接受常规全身麻醉,试验组在此基础上辅以羟考酮注射液超前镇痛。对比分析两组患者术后0.5 h(T1)、1 h(T2)、2 h(T3)、4 h(T4)等时间点疼痛程度和苏醒期不良反应发生率的差异性。结果:两组在T1时VAS评分无统计学意义(P>0.05)。试验组在T2、T3、T4时VAS评分明显低于对照组,差异有统计学意义(P<0.05)。试验组苏醒期不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论:在开胸手术超前镇痛中应用羟考酮注射液可缓解患者术后疼痛程度,减少苏醒期不良反应,对患者的术后康复有益。 Objective:To analyze oxycodone injection in preemptive analgesia in thoracic surgery.Methods:80 patients with thoracotomy were selected from June 2012 to May 2014.They were randomly divided into two groups.Patients in the control group received conventional general anesthesia,and patients in the experimental group supplemented with oxycodone injection preemptive analgesia on this basis.We compared two groups of patients after0.5 h(T1)、1 h(T2)、2 h(T3)、4 h(T4)and other point in time the degree of pain and recovery period incidence of adverse reactions differences.Results:Two groups in T1 VAS scores had no statistical significance(P>0.05).Patients in the experimental group in T2,T3,T4 VAS score was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).The adverse reaction rate of experimental group patients in recovery period was significantly lower than the control group,and the difference was statistically significant(P<0.05).Conclusion:In thoracotomy preemptive use of oxycodone injection can relieve pain patients,reducing wake of adverse reactions.It is benefit to patients.
出处 《中国社区医师》 2015年第15期36-37,共2页 Chinese Community Doctors
关键词 羟考酮注射液 开胸手术 超前镇痛 应用效果 Oxycodone injection Thoracotomy Preemptive analgesia Application effect
  • 相关文献

参考文献6

二级参考文献46

  • 1郑宏,王江,曹兴华,芮建中,刘进.国人靶控输注异丙酚的群体药代动力学[J].中华麻醉学杂志,2004,24(5):332-334. 被引量:43
  • 2李淑琴,张利勇,王保国.丙泊酚诱导期不良反应的多中心、大样本调查[J].临床麻醉学杂志,2006,22(10):738-739. 被引量:74
  • 3王云,于军.瑞芬太尼用于全凭静脉麻醉对鼻内镜手术患者苏醒的影响[J].实用诊断与治疗杂志,2007,21(2):84-85. 被引量:16
  • 4Dyszkiewicz W,Pawlak K,Gasiorowski L.Early post-pneumonectomy complications in the elderly[J].Eur J Cardiothorac Surg,2000,17(3):246-250.
  • 5Solca M.Acute pain management:unmet needs and new advances in pain management[J].Eur J Anaest Hesiol Suppl,2002,25(8):3-10.
  • 6Hutchins FI.Abdominal myomectomy as a treatment for symptomatic uterine fibroids[J].Obste Gynecol Clin N Am,1995,22(4):781-783.
  • 7Ong CK,Lirk P,Seymour RA,et al.The efficacy of preemptive analgesia for acute postoperative pain management:a meta-analysis[J].Anesth Analg,2005,100(3):757-773.
  • 8Yamada T,Alper DH,Laine L,et al.Textbook of gastroenterology[M].3ed.Philadelphia:Lippincott Williams & Wilkins Publishers,1999:1722.
  • 9Cheng HF,Harris RC.Cyclooxygenases,the kindney,and hypertension[J].Hypertension,2004,43(3):525-530.
  • 10Akhund L,Quinet RJ,Ishaq S.Celecoxib-related renal papillary necrosis[J].Arch Int Med,2003,163(1):114-115.

共引文献49

同被引文献56

  • 1谭建强,王迎虎,玄光日.瑞芬太尼药效学药理学及临床应用[J].河北医药,2009,31(21):2973-2975. 被引量:29
  • 2刘艳丽,颜玲娣,吴春福,宫泽辉.不同阿片受体在羟考酮引起小鼠高活动性和镇痛过程中的作用[J].中国药理学通报,2007,23(11):1484-1489. 被引量:10
  • 3Riley J,Ross JR,Rutter D,et al.No pain relief from morphine Individual variation in sensitivity to morphine and the need to switch to an alternative opioid in cancer patients[J].Support Care Cancer,2006,14(1):56-64.
  • 4Lalovic B,Kharasch E,Hoffer C,et al.Pharmcokinetics and pharmacodynamics of oral oxycodone in healthy human subjects:role of circulating active metabolites[J].Clin Pharma-col Ther,2006,79(5):461-479.
  • 5Peckham EM,Traynor JR.Comparison of the antinocicep-tive response to morphine and morphine-like compounds in male and femals Sprague-Dawley rats[J].J Pharmacol Exp Ther.2006,316(3):1195-1201.
  • 6Gaveriaux-Ruffc,Kieffer BL.Opioid receptor genes inactivated in mice[J].The highlights,Neurpeptides,2002,36(2-3):62-71.
  • 7Kalso E.Oxycodone.J Pain Symptom Manage[J].2005,29(5Supple):S47-56.
  • 8Billings JA.Humane terminal extubation reconsidered:the role for preemptive analgesia and sedation[J].Crit Care Med,2012(40):625-630.
  • 9Lenz H,Sandvik L,Qvigstad E,et al.A comparison of in-travenous oxycodone and intravenous morphine in patient-con-trolled postoperative analgesia after laparoscopic hysterectomy[J].Anesth Analg,2009,109(4):1279-1283.
  • 10McNieol E, Horowicz-Mehler N, Fisk RA, et al. Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review[J]. J Pain, 2003,4(5): 231-256.

引证文献5

二级引证文献23

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部